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Sertraline accumulation and effects in the estuarine decapod Carcinusmaenas: Importance of the history of exposure to chemical stress

2015-02Journal article Restricted access
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dc.contributor.authorRodrigues, Aurélie P.
dc.contributor.authorSantos, Lúcia H.M.L.M.
dc.contributor.authorRamalhosa, Maria João
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorGuimarães, Laura
dc.date.accessioned2015-12-28T14:03:34Z
dc.date.available2015-12-28T14:03:34Z
dc.date.issued2015-02
dc.description.abstractSertraline is widely prescribed worldwide and frequently detected in aquatic systems. There is, however, a remarkable gap of information on its potential impact on estuarine and coastal invertebrates. This study investigated sertraline accumulation and effects in Carcinus maenas. Crabs from a moderately contaminated (Lima) and a low-impacted (Minho) estuary were exposed to environmental and high levels of sertraline (0.05, 5, 500 μg L−1). A battery of biomarkers related to sertraline mode of action was employed to assess neurotransmission, energy metabolism, biotransformation and oxidative stress pathways. After a seven-day exposure, sertraline accumulation in crabs’ soft tissues was found in Lima (5 μg L−1: 15.3 ng L−1 ww; 500 μg L−1: 1010 ng L−1 ww) and Minho (500 μg L−1: 605 ng L−1 ww) animals. Lima crabs were also more sensitive to sertraline than those from Minho, exhibiting decreased acetylcholinesterase activity, indicative of ventilatory and locomotory dysfunction, inhibition of anti-oxidant enzymes and increased oxidative damage at ≥0.05 μg L−1. The Integrated Biomarker Response (IBR) index indicated their low health status. In addition, Minho crabs showed non-monotonic responses of acetylcholinesterase suggestive of hormesis. The results pointed an influence of the exposure history on differential sensitivity to sertraline and the need to perform evaluations with site-specific ecological receptors to increase relevance of risk estimations when extrapolating from laboratory to field conditions.pt_PT
dc.identifier.doi10.1016/j.jhazmat.2014.08.035pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/7265
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.ispartofseriesJournal of Hazardous Materials;Vol. 283
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0304389414006918pt_PT
dc.subjectBioaccumulationpt_PT
dc.subjectCholinergic neurotransmissionpt_PT
dc.subjectOxidative stresspt_PT
dc.subjectExposure historypt_PT
dc.subjectRisk assessmentpt_PT
dc.subjectInvertebratespt_PT
dc.titleSertraline accumulation and effects in the estuarine decapod Carcinusmaenas: Importance of the history of exposure to chemical stresspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage358pt_PT
oaire.citation.startPage350pt_PT
oaire.citation.titleJournal of Hazardous Materialspt_PT
oaire.citation.volume283pt_PT
person.familyNameRamalhosa
person.familyNameDelerue-Matos
person.givenNameMaria João
person.givenNameCristina
person.identifier.ciencia-id421A-C491-F45B
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0002-1951-3557
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridD-8293-2013
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id35488836000
person.identifier.scopus-author-id6603741848
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationda678924-3a20-496e-bc38-a9e2b39399b8
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication.latestForDiscovery09f6a7bd-2f15-42b0-adc5-04bd22210519

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