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Effects and bioaccumulation of gold nanoparticles in the gilthead seabream (Sparus aurata) – Single and combined exposures with gemfibrozil

2019-01Journal article Open access
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dc.contributor.authorBarreto, A.
dc.contributor.authorLuis, L.G.
dc.contributor.authorPinto, E.
dc.contributor.authorAlmeida, A.
dc.contributor.authorPaíga, Paula
dc.contributor.authorSantos, Lúcia H.M.L.M.
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorTrindade, T.
dc.contributor.authorSoares, A.M.V.M.
dc.contributor.authorHylland, K.
dc.contributor.authorLoureiro, S.
dc.contributor.authorOliveira, M.
dc.date.accessioned2020-10-30T11:57:21Z
dc.date.available2020-10-30T11:57:21Z
dc.date.issued2019-01
dc.description.abstractGold nanoparticles (AuNPs) are found in a wide range of applications and therefore expected to present increasing levels in the environment. There is however limited knowledge concerning the potential toxicity of AuNPs as well as their combined effects with other pollutants. Hence, the present study aimed to investigate the effects of AuNPs alone and combined with the pharmaceutical gemfibrozil (GEM) on different biological responses (behaviour, neurotransmission, biotransformation and oxidative stress) in one of the most consumed fish in southern Europe, the seabream Sparus aurata. Fish were exposed for 96 h to waterborne 40 nm AuNPs with two coatings - citrate and polyvinylpyrrolidone (PVP), alone or combined with GEM. Antioxidant defences were induced in liver and gills upon both AuNPs exposure. Decreased swimming performance (1600 μg.L-1) and oxidative damage in gills (4 and 80 μg.L-1) were observed following exposure to polyvinylpyrrolidone coated gold nanoparticles (PVP-AuNPs). Generally, accumulation of gold in fish tissues and deleterious effects in S. aurata were higher for PVP-AuNPs than for cAuNPs exposures. Although AuNPs and GEM combined effects in gills were generally low, in liver, they were higher than the predicted. The accumulation and effects of AuNPs showed to be dependent on the size, coating, surface charge and aggregation/agglomeration state of nanoparticles. Additionally, it was tissue' specific and dependent on the presence of other contaminants. Although, gold intake by humans is expected to not exceed the estimated tolerable daily intake, it is highly recommended to keep it on track due to the increasing use of AuNPs.pt_PT
dc.description.sponsorshipThis research was supported through the COMPETE – Operational Competitiveness Program and national funds through FCT – Foundation for Science and Technology, under the project “NANOAu – Effects of Gold Nanoparticles to Aquatic Organisms” (FCT PTDC/MAR-EST/3399/2012) (FCOMP-01-0124-FEDER-029435), through FCT/MCTES through national funds (PIDDAC) and the cofounding by FEDER, within the PT2020 Partnership Agreement and Compete 2020 to CESAM (UID/AMB/50017 – POCI-01-0145-FEDER-007638). A. Barreto has a doctoral fellowship from FCT (SFRH/BD/97624/2013); L. G. Luis had a fellowship from FCT (BI/UI88/6881/2014). MO has financial support of the program Investigator FCT, co-funded by the Human Potential Operational Programme and European Social Fund (IF/00335(2015).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.chemosphere.2018.09.175pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/16389
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0045653518318411?via%3Dihubpt_PT
dc.subjectEmerging contaminantspt_PT
dc.subjectMixturespt_PT
dc.subjectNanoparticle coatingpt_PT
dc.subjectFate Toxicitypt_PT
dc.titleEffects and bioaccumulation of gold nanoparticles in the gilthead seabream (Sparus aurata) – Single and combined exposures with gemfibrozilpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT
oaire.citation.endPage260pt_PT
oaire.citation.startPage248pt_PT
oaire.citation.titleChemospherept_PT
oaire.citation.volume215pt_PT
oaire.fundingStream5876
person.familyNamePaíga
person.familyNameSantos
person.familyNameDelerue-Matos
person.givenNamePaula
person.givenNameLúcia
person.givenNameCristina
person.identifier1668889
person.identifier554739
person.identifier.ciencia-id331A-5D6A-D3C8
person.identifier.ciencia-id201F-83C4-2FAF
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0002-9593-1355
person.identifier.orcid0000-0002-7013-8852
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridQ-4930-2018
person.identifier.ridK-6784-2013
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id6506638953
person.identifier.scopus-author-id55947204900
person.identifier.scopus-author-id6603741848
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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