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Effects of single and combined exposures of gold (nano versus ionic form) and gemfibrozil in a liver organ culture of Sparus aurata

2020-09-14Journal article Restricted access
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dc.contributor.authorBarreto, A.
dc.contributor.authorCarvalho, A.
dc.contributor.authorSilva, D.
dc.contributor.authorPinto, E.
dc.contributor.authorAlmeida, A.
dc.contributor.authorPaíga, P.
dc.contributor.authorCorreia-Sá, L.
dc.contributor.authorDelerue-Matos, C.
dc.contributor.authorTrindade, T.
dc.contributor.authorSoares, A.M.V.M.
dc.contributor.authorHylland, K.
dc.contributor.authorLoureiro, S.
dc.contributor.authorOliveira, M.
dc.date.accessioned2020-12-28T11:06:36Z
dc.date.available2022-09-14T00:30:55Z
dc.date.issued2020-09-14
dc.description.abstractIn vitro methods have gained rising importance in ecotoxicology due to ethical concerns. The aim of this study was to assess the single and combined in vitro effects of gold, as nanoparticle (AuNPs) and ionic (Au+) form, and the pharmaceutical gemfibrozil (GEM). Sparus aurata liver organ culture was exposed to gold (4 to 7200 μg·L−1), GEM (1.5 to 15,000 μg·L−1) and combination 80 μg·L−1 gold +150 μg·L−1 GEM for 24 h. Endpoints related with antioxidant status, peroxidative/genetic damage were assessed. AuNPs caused more effects than Au+, increasing catalase and glutathione reductase activities and damaging DNA and cellular membranes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.marpolbul.2020.111665pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/16622
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0025326X20307839?via%3Dihubpt_PT
dc.subjectFish liver culturept_PT
dc.subjectGilthead seabreampt_PT
dc.subjectNanotoxicologyIonic goldpt_PT
dc.subjectOxidative stresspt_PT
dc.subjectDNA integritypt_PT
dc.titleEffects of single and combined exposures of gold (nano versus ionic form) and gemfibrozil in a liver organ culture of Sparus auratapt_PT
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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