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Evaluation of solubility and partition properties of ampicillin-based ionic liquids

2013Journal article Open access
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dc.contributor.authorFlorindo, Catarina
dc.contributor.authorAraújo, João
dc.contributor.authorAlves, Filipa
dc.contributor.authorMatos, Carla
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorNoronha, João Paulo
dc.contributor.authorPetrovski, Zeljko
dc.contributor.authorBranco, Luís
dc.contributor.authorRebelo, Luís
dc.contributor.authorMarrucho, Isabel
dc.date.accessioned2014-03-07T10:07:41Z
dc.date.available2014-03-07T10:07:41Z
dc.date.issued2013
dc.description.abstractIn order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25 °C and 37 °C (body temperature) as well as octanol–water partition coefficients (Kow's) and HDPC micelles partition at 25 °C were measured. Critical micelle concentrations (CMC's) in water at 25 °C and 37 °C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements.por
dc.identifier.doi10.1016/j.ijpharm.2013.08.010pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/4155
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.ispartofseriesInternational Journal of Pharmaceutics; Vol. 456, Nº 2
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0378517313007321por
dc.subjectActive pharmaceutical ionic liquidspor
dc.subjectCritical micelle concentrationspor
dc.subjectOctanol–water partition coefficientspor
dc.subjectBioavailabilitypor
dc.subjectSolubilitypor
dc.titleEvaluation of solubility and partition properties of ampicillin-based ionic liquidspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage559por
oaire.citation.issueNº 2por
oaire.citation.startPage553por
oaire.citation.titleInternational Journal of Pharmaceuticspor
oaire.citation.volumeVol. 456por
person.familyNameFerraz
person.familyNamePrudêncio
person.givenNameRicardo
person.givenNameCristina
person.identifier1200571
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.orcid0000-0002-1761-117X
person.identifier.orcid0000-0002-9920-936X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
person.identifier.scopus-author-id6508057930
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isAuthorOfPublication.latestForDiscoverya5a8faa7-12a5-4b1c-bced-44c895677397

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