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Substance P antagonist improves both obesity and asthma in a mouse model

2012-11Artigo científico Acesso aberto
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dc.contributor.authorRamalho, R.
dc.contributor.authorAlmeida, Joana
dc.contributor.authorBeltrão, M.
dc.contributor.authorPirraco, A.
dc.contributor.authorCosta, R.
dc.contributor.authorSokhatska, O.
dc.contributor.authorGuardão, L.
dc.contributor.authorPalmares, C.
dc.contributor.authorGuimarães, J. T.
dc.contributor.authorDelgado, L.
dc.contributor.authorMoreira, A.
dc.contributor.authorSoares, R.
dc.date.accessioned2021-09-28T09:00:01Z
dc.date.available2021-09-28T09:00:01Z
dc.date.issued2012-11
dc.description.abstractEvidence suggests a causal relationship between obesity and asthma; however, the underlying mechanisms remain unknown. Substance P (SP), involved in neurogenic inflammation by acting through its receptor NK1-R, seems to participate in obese–asthma phenotype in mice. To evaluate the effect of a selective substance P receptor antagonist on a mouse model of diet-induced obesity and asthma. Diet-induced obese Balb/c mice were sensitized and challenged with ovalbumin (OVA) and treated with a selective NK1-R antagonist or placebo. Serum glucose, insulin, IL-6, resistin, and OVA-specific IgE levels were quantified. A score for peribronchial inflammation in lung histology was used. Cells were counted in bronchoalveolar lavage fluid. Adipocyte sizes were measured. Ovalbumin-obese mice treated with NK1-R antagonist had lower weight (P = 0.0002), reduced daily food intake (P = 0.0021), reduced daily energy intake (P = 0.0021), reduced surface adipocyte areas (P < 0.0001), lower serum glucose (P = 0.04), lower serum insulin (P = 0.03), lower serum IL-(P = 0.0022), lower serum resistin (P = 0.0043), lower serum OVA-specific IgE (P = 0.035), and lower peribronchial inflammation score (P < 0.0001) than nontreated OVA-obese mice. We observed an interaction between obesity, allergen sensitization, and treatment with NK1-R antagonist for metabolic and systemic biomarkers, and for allergen sensitization and bronchial inflammation, showing a synergy between these variables. In an experimental model of obesity and asthma in mice, NK1-R blockade improved metabolic and systemic biomarkers, as well as allergen sensitization and bronchial inflammation. These positive effects support a common pathway in the obese–asthma phenotype and highlight SP as a target with potential clinical interest in the obese–asthma epidemics.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRamalho, R., Almeida, J., Beltrão, M., Pirraco, A., Costa, R., Sokhatska, O., Guardão, L., Palmares, C., Guimarães, J. T., Delgado, L., Moreira, A., & Soares, R. (2013). Substance P antagonist improves both obesity and asthma in a mouse model. Allergy, 68(1), 48-54. https://doi.org/https://doi.org/10.1111/all.12052pt_PT
dc.identifier.doi10.1111/all.12052pt_PT
dc.identifier.issn1398-9995
dc.identifier.urihttp://hdl.handle.net/10400.22/18592
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1111/all.12052pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimal modelpt_PT
dc.subjectAsthmapt_PT
dc.subjectNK1-R antagonistpt_PT
dc.subjectObesitypt_PT
dc.subjectSubstance Ppt_PT
dc.subjectTreatmentpt_PT
dc.titleSubstance P antagonist improves both obesity and asthma in a mouse modelpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage54pt_PT
oaire.citation.startPage48pt_PT
oaire.citation.titleAllergypt_PT
oaire.citation.volume68pt_PT
person.familyNameALMEIDA
person.givenNameJOANA
person.identifier.ciencia-id1317-637D-8EE0
person.identifier.orcid0000-0001-8043-9053
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication5ec466aa-7e58-47b6-a45b-b9ee3e6f6552
relation.isAuthorOfPublication.latestForDiscovery5ec466aa-7e58-47b6-a45b-b9ee3e6f6552

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