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Modelling the impact of NETosis during the initial stage of systemic Lupus erythematosus

2024-04-28Journal article Open access
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dc.contributor.authorSuvandjieva, Vladimira
dc.contributor.authorTsacheva, Ivanka
dc.contributor.authorSantos, Marlene
dc.contributor.authorKararigas, Georgios
dc.contributor.authorRashkov, Peter
dc.date.accessioned2024-04-29T08:28:44Z
dc.date.embargo2025-04-02
dc.date.issued2024-04-28
dc.description.abstractThe development of autoimmune diseases often takes years before clinical symptoms become detectable. We propose a mathematical model for the immune response during the initial stage of Systemic Lupus Erythematosus which models the process of aberrant apoptosis and activation of macrophages and neutrophils. NETosis is a type of cell death characterised by the release of neutrophil extracellular traps, or NETs, containing material from the neutrophil’s nucleus, in response to a pathogenic stimulus. This process is hypothesised to contribute to the development of autoimmunogenicity in SLE. The aim of this work is to study how NETosis contributes to the establishment of persistent autoantigen production by analysing the steady states and the asymptotic dynamics of the model by numerical experiment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSuvandjieva, V., Tsacheva, I., Santos, M., Kararigas, G., & Rashkov, P. (2024). Modelling the impact of NETosis during the initial stage of systemic Lupus erythematosus. Bulletin of Mathematical Biology, 86(6), 66. https://doi.org/10.1007/s11538-024-01291-3pt_PT
dc.identifier.doi10.1007/s11538-024-01291-3pt_PT
dc.identifier.eissn1522-9602
dc.identifier.issn0092-8240
dc.identifier.urihttp://hdl.handle.net/10400.22/25420
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s11538-024-01291-3?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20240428&utm_content=10.1007%2Fs11538-024-01291-3pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectLupuspt_PT
dc.subjectImmune responsept_PT
dc.subjectBifurcation analysispt_PT
dc.subjectAntigen presentationpt_PT
dc.titleModelling the impact of NETosis during the initial stage of systemic Lupus erythematosuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleBulletin of Mathematical Biologypt_PT
oaire.citation.volume86 (6)pt_PT
person.familyNameSantos
person.givenNameMarlene
person.identifier1508370
person.identifier.ciencia-id8311-B967-31C4
person.identifier.orcid0000-0001-5020-5942
person.identifier.scopus-author-id57110502000
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublication.latestForDiscovery8ce9ee39-a4c6-46ae-99e2-49397b550f1b

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