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Antiproliferative organic salts derived from betulinic acid: Disclosure of an ionic liquid selective against lung and liver cancer cells

2019Journal article Open access
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dc.contributor.authorSilva, Ana Teresa
dc.contributor.authorCerqueira, Maria João
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorFernandes, Maria Helena
dc.contributor.authorCosta-Rodrigues, João
dc.contributor.authorTeixeira, Cátia
dc.contributor.authorGomes, Paula
dc.contributor.authorFerraz, Ricardo
dc.date.accessioned2019-07-31T14:51:42Z
dc.date.available2019-07-31T14:51:42Z
dc.date.issued2019
dc.description.abstractIn the last few years, we have been witnessing an increasing interest in ionic liquids (ILs) and organic salts, given their potential applications in biological and pharmaceutical sciences. We report the synthesis and in vitro evaluation of novel organic salts combining betulinate, known for its anticancer properties, with antimalarial drugs, primaquine, chloroquine, and mepacrine, and also with the trihexyltetradecylphosphonium ([P6,6,6,14]) cation. The salts were screened for their in vitro activity against tumor lines HepG2 (liver), MG63 (osteosarcoma), T47D (breast), A459 (lung), and RKO (colon), and also on normal human fibroblasts. All betulinates prepared displayed antiproliferative properties, with the trihexyltetradecylphosphonium betulinate standing out for its higher selectivity. This unprecedented disclosure of a betulinic acid (BA)-derived IL with selective antitumor activity constitutes a relevant first step toward development of novel anticancer therapies based on BA-derived IL.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, A. T., Cerqueira, M. J., Prudêncio, C., Fernandes, M. H., Costa-Rodrigues, J., Teixeira, C., Gomes, P., & Ferraz, R. (2019). Antiproliferative organic salts derived from betulinic acid: Disclosure of an ionic liquid selective against lung and liver cancer cells. ACS Omega, 4(3), 5682–5689. https://doi.org/10.1021/acsomega.8b03691
dc.identifier.doi10.1021/acsomega.8b03691pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14516
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Chemical Societypt_PT
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acsomega.8b03691pt_PT
dc.subjectIonic liquidspt_PT
dc.subjectOrganic saltspt_PT
dc.subjectAnticancer therapiespt_PT
dc.titleAntiproliferative organic salts derived from betulinic acid: Disclosure of an ionic liquid selective against lung and liver cancer cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage5689pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage5682pt_PT
oaire.citation.titleACS Omegapt_PT
oaire.citation.volume4pt_PT
person.familyNameCerqueira
person.familyNamePrudêncio
person.familyNameCosta-Rodrigues
person.familyNameFerraz
person.givenNameMaria João
person.givenNameCristina
person.givenNameJoao
person.givenNameRicardo
person.identifier1200571
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.ciencia-id7412-B006-2120
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.orcid0009-0003-5744-0875
person.identifier.orcid0000-0002-9920-936X
person.identifier.orcid0000-0003-1375-8067
person.identifier.orcid0000-0002-1761-117X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id6508057930
person.identifier.scopus-author-id8558383400
person.identifier.scopus-author-id24464208500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication80b7a55a-377a-4606-9c86-843fdf3bc97d
relation.isAuthorOfPublication881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isAuthorOfPublicationce85cc8f-09f3-4c26-aeaf-6128971acf68
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication.latestForDiscovery80b7a55a-377a-4606-9c86-843fdf3bc97d

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