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Lipofuscin-Type Pigment as a Marker of Colorectal Cancer

2020-10-31Journal article Open access
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dc.contributor.authorCarvalho, Sónia
dc.contributor.authorCarneiro, Isa
dc.contributor.authorHenrique, Rui
dc.contributor.authorTuchin, Valery
dc.contributor.authorOliveira, Luís
dc.date.accessioned2021-08-30T10:28:01Z
dc.date.available2021-08-30T10:28:01Z
dc.date.issued2020-10-31
dc.description.abstractThe study of the optical properties of biological tissues for a wide spectral range is necessary for the development and planning of noninvasive optical methods to be used in clinical practice. In this study, we propose a new method to calculate almost all optical properties of tissues as a function of wavelength directly from spectral measurements. Using this method, and with the exception of the reduced scattering coefficient, which was obtained by traditional simulation methods, all the other optical properties were calculated in a simple and fast manner for human and pathological colorectal tissues. The obtained results are in good agreement with previous published data, both in magnitude and in wavelength dependence. Since this method is based on spectral measurements and not on discrete-wavelength experimental data, the calculated optical properties contain spectral signatures that correspond to major tissue chromophores such as DNA and hemoglobin. Analysis of the absorption bands of hemoglobin in the wavelength dependence of the absorption spectra of normal and pathological colorectal mucosa allowed to identify differentiated accumulation of a pigment in these tissues. The increased content of this pigment in the pathological mucosa may be used for the future development of noninvasive diagnostic methods for colorectal cancer detection.pt_PT
dc.description.sponsorshipRFBR; FCTpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCarvalho, S.; Carneiro, I.; Henrique, R.; Tuchin, V.; Oliveira, L. Lipofuscin-Type Pigment as a Marker of Colorectal Cancer. Electronics 2020, 9, 1805. https://doi.org/10.3390/electronics9111805pt_PT
dc.identifier.doi10.3390/electronics9111805pt_PT
dc.identifier.eissn2079-9292
dc.identifier.urihttp://hdl.handle.net/10400.22/18257
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation18–29–02060 MKpt_PT
dc.relationCT-UIDB/04730/2020pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2079-9292/9/11/1805pt_PT
dc.subjectOptical properties of tissuespt_PT
dc.subjectTissue spectroscopypt_PT
dc.subjectDifferentiated pigment contentpt_PT
dc.subjectColorectal cancerpt_PT
dc.subjectOptical cancer detectionpt_PT
dc.subjectAbsorption coefficientpt_PT
dc.subjectScattering coefficientpt_PT
dc.subjectScattering anisotropypt_PT
dc.subjectLight penetration depthpt_PT
dc.titleLipofuscin-Type Pigment as a Marker of Colorectal Cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11pt_PT
oaire.citation.titleElectronicspt_PT
oaire.citation.volume9pt_PT
person.familyNameOliveira
person.givenNameLuís
person.identifier414820
person.identifier.ciencia-idC312-F342-BD23
person.identifier.orcid0000-0003-0667-3428
person.identifier.ridB-7198-2017
person.identifier.scopus-author-id55853723900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4e2de4d7-142a-400f-8dbf-cd0ff9551093
relation.isAuthorOfPublication.latestForDiscovery4e2de4d7-142a-400f-8dbf-cd0ff9551093

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