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Advisor(s)
Abstract(s)
The study of the optical properties of biological tissues for a wide spectral range is necessary
for the development and planning of noninvasive optical methods to be used in clinical practice.
In this study, we propose a new method to calculate almost all optical properties of tissues as a function
of wavelength directly from spectral measurements. Using this method, and with the exception of
the reduced scattering coefficient, which was obtained by traditional simulation methods, all the
other optical properties were calculated in a simple and fast manner for human and pathological
colorectal tissues. The obtained results are in good agreement with previous published data, both in
magnitude and in wavelength dependence. Since this method is based on spectral measurements
and not on discrete-wavelength experimental data, the calculated optical properties contain spectral
signatures that correspond to major tissue chromophores such as DNA and hemoglobin. Analysis of
the absorption bands of hemoglobin in the wavelength dependence of the absorption spectra of
normal and pathological colorectal mucosa allowed to identify differentiated accumulation of a
pigment in these tissues. The increased content of this pigment in the pathological mucosa may be
used for the future development of noninvasive diagnostic methods for colorectal cancer detection.
Description
Keywords
Optical properties of tissues Tissue spectroscopy Differentiated pigment content Colorectal cancer Optical cancer detection Absorption coefficient Scattering coefficient Scattering anisotropy Light penetration depth
Pedagogical Context
Citation
Carvalho, S.; Carneiro, I.; Henrique, R.; Tuchin, V.; Oliveira, L. Lipofuscin-Type Pigment as a Marker of Colorectal Cancer. Electronics 2020, 9, 1805. https://doi.org/10.3390/electronics9111805