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Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials

2019Journal article Open access
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dc.contributor.authorFonte, Mélanie
dc.contributor.authorFagundes, Natália
dc.contributor.authorGomes, Ana
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorAraújo, Maria João
dc.contributor.authorGomes, Paula
dc.contributor.authorTeixeira, Cátia
dc.date.accessioned2019-07-01T12:34:32Z
dc.date.available2022-05-02T00:30:47Z
dc.date.issued2019
dc.description.abstractA multi-step synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines that, to the best of our knowledge, has no precedence in the literature, has been developed. The target structures are likely to reveal interesting biological activities in the near future, not only due to their mepacrine-like core, but also because they embed simultaneously the pharmacophores of chloroquine and primaquine, antimalarial drugs that act at different stages of malaria infection.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFonte, M., Fagundes, N., Gomes, A., Ferraz, R., Prudêncio, C., Araújo, M. J., Gomes, P., & Teixeira, C. (2019). Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials. Tetrahedron Letters, 60(17), 1166–1169. https://doi.org/10.1016/j.tetlet.2019.03.052
dc.identifier.doi10.1016/j.tetlet.2019.03.052pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14182
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationNORTE-01-0145-FEDER-000024pt_PT
dc.relationA small couple against the big three
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0040403919302801pt_PT
dc.subjectAcridinept_PT
dc.subjectAntimalarialpt_PT
dc.subjectHeteroaromaticpt_PT
dc.subjectHeterocyclic chemistrypt_PT
dc.subjectMepacrinept_PT
dc.subjectQuinacrinept_PT
dc.titleDevelopment of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarialspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleA small couple against the big three
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTM-SAL%2F29786%2F2017/PT
oaire.citation.endPage1169pt_PT
oaire.citation.issue17pt_PT
oaire.citation.startPage1166pt_PT
oaire.citation.titleTetrahedron Letterspt_PT
oaire.citation.volume60pt_PT
oaire.fundingStream5876
oaire.fundingStream3599-PPCDT
person.familyNameFerraz
person.familyNamePrudêncio
person.givenNameRicardo
person.givenNameCristina
person.identifier1200571
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.orcid0000-0002-1761-117X
person.identifier.orcid0000-0002-9920-936X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
person.identifier.scopus-author-id6508057930
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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