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Tissue mimicking phantoms for biomedical optics: A systematic review of inverse adding–doubling characterization and clinical relevance

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datacite.subject.fosCiências Médicas
datacite.subject.fosEngenharia e Tecnologia
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorGarcía-Cortés, Elvis
dc.contributor.authorPérez-Sansalvador, Julio
dc.contributor.authorSpezzia-Mazzocco, Teresita
dc.contributor.editorPopp, Jürgen
dc.date.accessioned2026-09-07T09:52:41Z
dc.date.available2026-09-07T09:52:41Z
dc.date.issued2026
dc.description.abstractTissue mimicking phantoms are essential for calibration and clinical translation of biophotonic techniques. Although the inverse adding–doubling (IAD) method is widely regarded as a reference standard for determining absorption and reduced scattering coefficients, significant inter-laboratory variability persists due to differences in integrating-sphere configurations, loss-compensation strategies, and model assumptions. This PRISMA-guided review (2015–2025) analyzes 10 experimental studies and proposes a unified comparison framework based on scattering power-law parameters (a, b) to relate phantom fabrication to clinically relevant optical targets. Nonlinear regression of continuous u's spectra shows that selected PVC plastisol formulations reproduce dermal-like scattering slopes and that the power-law model provides consistent spectral descriptions (R2= 0.98). By linking measurement methodology, spectral fitting, and mapping in (a, b) space, this work provides a practical framework to interpret variability and guide development of tissue-equivalent phantoms for reliable calibration of biophotonic devices.eng
dc.description.sponsorshipThis work was financed by National Funds through the Portuguese funding agency, FCT—Fundação para a Ciência e a Tecnologia, within projects LA/P/0063/2020 (DOI 10.54499/LA/P/0063/2020), UIDB/50014/2020 (DOI 10.54499/UIDB/50014/2020), and UIDP/50014/2020 (DOI 10.54499/UIDP/50014/2002). Elvis A. García-Cortés acknowledges support from a postgraduate fellowship of the Secretaría de Ciencia, Humanidades, Tecnología e Innovación (SECIHTI), Mexico (grant 923302).
dc.identifier.citationGarcía-Cortés, E.A., Oliveira, L.M., Pérez-Sansalvador, J.C., and, Spezzia-Mazzocco, T. (2026). Tissue mimicking phantoms for biomedical optics: A systematic review of inverse adding–doubling characterization and clinical relevance. Journal of Biophotonics, vol. 19(4). https://doi.org/10.1002/jbio.70261
dc.identifier.doi10.1002/jbio.70261
dc.identifier.issn1864-063X
dc.identifier.urihttp://hdl.handle.net/10400.22/32682
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relationINESC TEC - Institute for Systems and Computer Engineering, Technology and Science (INESC TEC)
dc.relationINESC TEC- Institute for Systems and Computer Engineering, Technology and Science
dc.relationINESC TEC- Institute for Systems and Computer Engineering, Technology and Science
dc.relation.hasversionhttps://onlinelibrary.wiley.com/doi/10.1002/jbio.70261
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectbiomedical engineering
dc.subjectimaging phantoms
dc.subjectnear-infrared spectroscopy
dc.subjectoptical coherence tomography
dc.subjectoptical imaging
dc.subjectoptical phenomena
dc.subjectradiation scattering
dc.titleTissue mimicking phantoms for biomedical optics: A systematic review of inverse adding–doubling characterization and clinical relevanceeng
dc.typereview article
dspace.entity.typePublication
oaire.awardNumberLA/P/0063/2020
oaire.awardNumberUIDB/50014/2020
oaire.awardNumberUIDP/50014/2020
oaire.awardTitleINESC TEC - Institute for Systems and Computer Engineering, Technology and Science (INESC TEC)
oaire.awardTitleINESC TEC- Institute for Systems and Computer Engineering, Technology and Science
oaire.awardTitleINESC TEC- Institute for Systems and Computer Engineering, Technology and Science
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0063%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50014%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50014%2F2020/PT
oaire.citation.issue4
oaire.citation.titleJornal of Biophotonics
oaire.citation.volume19
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublicationb49886f4-f1ba-4508-a7a6-394627e030a2
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relation.isProjectOfPublication5efdbedb-4666-4d5b-94f0-0a938b0d5ce4
relation.isProjectOfPublication.latestForDiscoveryb49886f4-f1ba-4508-a7a6-394627e030a2

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