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Orientador(es)
Resumo(s)
Tissue mimicking phantoms are essential for calibration and clinical translation of biophotonic techniques. Although the inverse adding–doubling (IAD) method is widely regarded as a reference standard for determining absorption and reduced scattering coefficients, significant inter-laboratory variability persists due to differences in integrating-sphere configurations, loss-compensation strategies, and model assumptions. This PRISMA-guided review (2015–2025) analyzes 10 experimental studies and proposes a unified comparison framework based on scattering power-law parameters (a, b) to relate phantom fabrication to clinically relevant optical targets. Nonlinear regression of continuous u's spectra shows that selected PVC plastisol formulations reproduce dermal-like scattering slopes and that the power-law model provides consistent spectral descriptions (R2= 0.98).
By linking measurement methodology, spectral fitting, and mapping in (a, b) space, this work provides a practical framework to interpret variability and guide development of tissue-equivalent
phantoms for reliable calibration of biophotonic devices.
Descrição
Palavras-chave
biomedical engineering imaging phantoms near-infrared spectroscopy optical coherence tomography optical imaging optical phenomena radiation scattering
Contexto Educativo
Citação
García-Cortés, E.A., Oliveira, L.M., Pérez-Sansalvador, J.C., and, Spezzia-Mazzocco, T. (2026). Tissue mimicking phantoms for biomedical optics: A systematic review of inverse adding–doubling characterization and clinical relevance. Journal of Biophotonics, vol. 19(4). https://doi.org/10.1002/jbio.70261
Editora
Wiley