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Publication
Nanopartículas de grafeno para Terapia de Hipertermia Magnética
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Authors
Abstract(s)
A terapia de hipertermia magnética tem vindo a afirmar-se como uma estratégia promissora no
tratamento oncológico, baseada no aquecimento localizado de tecidos tumorais através da
aplicação de um campo magnético alternado sobre nanopartículas magnéticas dispersas num
meio fluido. Neste contexto, o presente trabalho teve como objetivo avaliar o comportamento
térmico de nanofluidos à base de grafeno funcionalizado, analisando a sua eficiência de
aquecimento e viabilidade para aplicações biomédicas.
Foram estudadas diferentes formulações de amostras com concentrações variáveis de grafeno,
bem como o impacto da centrifugação e do tipo de bobine de indução (estreita e larga) sobre
o desempenho térmico. A partir dos ensaios experimentais, foi registada a evolução temporal
da temperatura, permitindo comparar o diferencial térmico alcançado e identificar as condições
mais favoráveis à geração de calor.
Os resultados demonstraram diferenças significativas entre as amostras, evidenciando que
parâmetros como a concentração, o estado de dispersão e a geometria da bobine influenciam
fortemente a resposta térmica. Conclui-se que os nanofluidos de grafeno apresentam potencial
relevante para utilização em hipertermia magnética, desde que seja assegurada a estabilidade
coloidal e a homogeneidade do campo aplicado..
Magnetic hyperthermia has emerged as a promising strategy for cancer treatment, relying on the localized heating of tumour tissues through the application of an alternating magnetic field to magnetic nanoparticles dispersed in a fluid medium. In this context, the present work aimed to evaluate the thermal behaviour of graphene-based nanofluids, assessing their heating efficiency and feasibility for biomedical applications. Different sample formulations with variable graphene concentrations were analysed, as well as the effect of centrifugation and induction coil geometry (narrow and wide coils) on the thermal performance. Experimental assays recorded the temperature evolution over time, experimental tests recorded the temporal evolution of the temperature, allowing the analysis of the thermal differential achieved and the identification of the most favorable conditions for heat generation. The results revealed marked differences between samples, showing that parameters such as concentration, dispersion state and coil geometry significantly affect the heating response. Overall, graphene nanofluids demonstrate considerable potential for use in magnetic hyperthermia, provided that colloidal stability and magnetic field uniformity are ensured.
Magnetic hyperthermia has emerged as a promising strategy for cancer treatment, relying on the localized heating of tumour tissues through the application of an alternating magnetic field to magnetic nanoparticles dispersed in a fluid medium. In this context, the present work aimed to evaluate the thermal behaviour of graphene-based nanofluids, assessing their heating efficiency and feasibility for biomedical applications. Different sample formulations with variable graphene concentrations were analysed, as well as the effect of centrifugation and induction coil geometry (narrow and wide coils) on the thermal performance. Experimental assays recorded the temperature evolution over time, experimental tests recorded the temporal evolution of the temperature, allowing the analysis of the thermal differential achieved and the identification of the most favorable conditions for heat generation. The results revealed marked differences between samples, showing that parameters such as concentration, dispersion state and coil geometry significantly affect the heating response. Overall, graphene nanofluids demonstrate considerable potential for use in magnetic hyperthermia, provided that colloidal stability and magnetic field uniformity are ensured.
Description
Keywords
Magnetic hyperthermia SAR Graphene Nanofluids Magnetic induction Induced heat therapies Hipertermia magnética Grafeno Nanofluídos Indução magnética Terapias termo-induzidas