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Moving towards personalized medicine—The broad use of aptamers for targeted theranostic

2023-10-31Journal article Open access
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dc.contributor.authorSousa, André P.
dc.contributor.authorRocha, Ana C.
dc.contributor.authorAlmeida, Cátia
dc.contributor.authorCarneiro, Mariana C. C. G.
dc.contributor.authorPais, Patrick P.
dc.contributor.authorViana, Rejane
dc.contributor.authorFernandes, Rúben
dc.contributor.authorBarata, Pedro
dc.contributor.authorGestoso, Álvaro
dc.contributor.authorRamalho, Susana
dc.contributor.authorMartins-Mendes, Daniela
dc.contributor.authorBaylina, Pilar
dc.contributor.authorPereira, Ana Cláudia
dc.date.accessioned2024-04-08T14:07:57Z
dc.date.available2024-04-08T14:07:57Z
dc.date.issued2023-10-31
dc.description.abstractAptamers are short, single-stranded oligonucleotides synthesized in vitro from a randomized oligonucleotide library against a specific target. These molecules are capable of binding to a wide range of biological targets with high specificity and affinity. They present great advantages over antibodies with potential applications in research, diagnosis, and therapeutics. Specifically for tumors with late-stage identification and poor prognosis, like pancreatic cancer, the study of novel aptamers holds tremendous potential for cancer diagnosis and treatment. Along with cancer treatment, aptamers have also shown high potential in regulating the immune response and modulating several critical steps of signaling cascades, such as in immune checkpoints. In the context of microbiota and infection, aptamers are being studied to identify microbes and their metabolites. This assessment has the potential to improve the detection and management of infectious diseases while assisting us in better understanding health risks and treatment outcomes by tracking changes in the microbiota. In this review, the potential of aptamers is explored regarding their applications in cancer, immune, and microbiota therapy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSousa, A. P., Rocha, A. C., Almeida, C., Carneiro, M. C. C. G., Pais, P. P., Viana, R., Fernandes, R., Barata, P., Gestoso, Á., Ramalho, S., Martins-Mendes, D., Baylina, P., & Pereira, A. C. (2023). Moving towards personalized medicine—The broad use of aptamers for targeted theranostic. Applied Sciences, 13(21), Artigo 21. https://doi.org/10.3390/app132111933pt_PT
dc.identifier.doi10.3390/app132111933pt_PT
dc.identifier.eissn2076-3417
dc.identifier.urihttp://hdl.handle.net/10400.22/25305
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationPilar Baylina (P.B.) acknowledges on the behalf of the authors the support of Fundação para a Ciência e Tecnologia (FCT), Portuguese Government, under the Strategic Project Reference: UID/BIM/04293/2013. Pilar Baylina (P.B.) and R.F. was also supported by FEDER/02/SAICT/2020/072560. Ana Cláudia Pereira (A.C.P.) acknowledges the support of Fundação para a Ciência e Tecnologia (FCT), Portuguese Government, under the Strategic Project Reference: 2022.09032.PTDC. André P. Sousa acknowledges FCT for the PhD grant 2022.12441.BD. Ana C. Rocha acknowledges FCT for the PhD grant 2021.06521.BD. Patrick P. Pais acknowledges FCT for the PhD grant 2021.09498.BD. Susana Ramalho acknowledges LaBMI for the PhD grant LABMI/BI/2021/01 (NEURO4COVID).pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2076-3417/13/21/11933pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAptamerpt_PT
dc.subjectCancerpt_PT
dc.subjectImmune responsept_PT
dc.subjectMicrobiotapt_PT
dc.subjectSELEXpt_PT
dc.subjectTherapeuticpt_PT
dc.titleMoving towards personalized medicine—The broad use of aptamers for targeted theranosticpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage17pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleApplied Sciencespt_PT
oaire.citation.volume13(21)pt_PT
person.familyNameBAYLINA MACHADO
person.givenNamePILAR
person.identifier.ciencia-id1419-F23D-4920
person.identifier.orcid0000-0002-3740-862X
person.identifier.ridB-5134-2010
person.identifier.scopus-author-id56534079700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb1482a24-d9d8-419d-af68-6df1a75afb3f
relation.isAuthorOfPublication.latestForDiscoveryb1482a24-d9d8-419d-af68-6df1a75afb3f

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