Publicação
Biotechnological potential of Macroalgae associated Actinomycetota
| dc.contributor.author | Moreira, Gabriela Alves | |
| dc.contributor.author | Girão, Mariana | |
| dc.contributor.author | Eusébio, Nádia | |
| dc.contributor.author | Mendes, Marta V. | |
| dc.contributor.author | Carvalho, Maria de Fátima | |
| dc.contributor.author | Alves Moreira, Gabriela | |
| dc.date.accessioned | 2026-07-28T09:13:40Z | |
| dc.date.available | 2026-07-28T09:13:40Z | |
| dc.date.issued | 2026-05-29 | |
| dc.description.abstract | Actinomycetota are Gram-positive bacteria widely distributed across diverse environments, from ter-restrial to marine ecosystems, where they may occur as free-living organisms or in association with other organisms. This phylum is well-known for its remark-able biotechnological potential, with several members producing bioactive compounds such as antimicrobial and anticancer agents. However, macroalgae-associ-ated Actinomycetota remain underexplored despite having a metabolic potential comparable to free-living organisms.The main objective of this study was to explore the biosynthetic potential of 15 Actinomycetota isolates obtained from two marine macroalgae from the Por-tuguese coast, Codium tomentosum and Chondrus cris-pus, through the analysis of their genomes.Total DNA was sequenced using Illumina technology and 17 de novo genomes were assembled. Phyloge-nomic analysis identified 5 different genera, Actinoal-loteichus, Cellulosimicrobium, Kocuria, Nocardia and Streptomyces, with 3 putative novel species.Genome mining, using manually curated antiSMASH data, identified 452 biosynthetic gene clusters (BGCs) across 21 metabolite classes. Among the BGCs iden-tified are antimicrobial and anticancer compounds, siderophores and conserved metabolites. More than 60% of these BGCs have none or low similarity to pre-viously known compounds, which can be an indicator of novelty. Compared with Streptomyces, one of the most studied genera, non-Streptomyces genera exhib-ited a higher novelty percentage (ca. 80%).Additionally, BiG-SCAPE and clinker were used to visualize the data and assess the similarity between BGCs for the same compound in different strains.Overall, these results confirm that macroalgae-as-sociated Actinomycetota represent a valuable and underexplored source of new species and biosynthet-ic diversity, supporting further study of this bacterial group. | eng |
| dc.identifier.citation | Moreira, G. A., Girão, M., Eusébio, N., Mendes, M. V., & Carvalho, M. de F. (2026). Biotechnological potential of Macroalgae associated Actinomycetota. Book of Abstracts of the 8th Meeting on Medicinal Biotechnology, 5. https://edicoes.ipp.pt/index.php/books/catalog/book/251 | |
| dc.identifier.doi | 10.26537/ed.p.porto.251 | |
| dc.identifier.isbn | 978-989-9226-20-3 | |
| dc.identifier.uri | http://hdl.handle.net/10400.22/32623 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Politema | |
| dc.relation | UID/04423/2025; UID/PRR/04423/2025; 2023.04554.BDANA; 023.08302.CEECIND/CP2848/CT0019 | |
| dc.relation.hasversion | https://edicoes.ipp.pt/index.php/books/catalog/book/251 | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Actinomycetota | |
| dc.subject | Novelty | |
| dc.subject | Biosynthetic potential | |
| dc.title | Biotechnological potential of Macroalgae associated Actinomycetota | eng |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferenceDate | 2026-05-29 | |
| oaire.citation.conferencePlace | Porto | |
| oaire.citation.endPage | 5 | |
| oaire.citation.startPage | 5 | |
| oaire.citation.title | Book of Abstracts of the 8th Meeting on Medicinal Biotechnology | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| person.familyName | Alves Moreira | |
| person.givenName | Gabriela | |
| person.identifier.ciencia-id | F414-ECA9-CE09 | |
| person.identifier.orcid | 0000-0003-4542-2488 | |
| relation.isAuthorOfPublication | 81d45a76-6979-430f-81c4-e4afe7253cc4 | |
| relation.isAuthorOfPublication.latestForDiscovery | 81d45a76-6979-430f-81c4-e4afe7253cc4 |