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Colon tumor CD31 expression is associated with higher disease-free survival in patients with metabolic syndrome

2022-12Journal article Open access
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dc.contributor.authorSilva, Ana
dc.contributor.authorPereira, Sofia S.
dc.contributor.authorBrandão, José Ricardo
dc.contributor.authorBrochado, Paulo
dc.contributor.authorMonteiro, Mariana P.
dc.contributor.authorAraújo, António
dc.contributor.authorFaria, Gil
dc.date.accessioned2023-03-20T16:43:53Z
dc.date.available2023-03-20T16:43:53Z
dc.date.issued2022-12
dc.description.abstractMetabolic syndrome (MS) is recognized as a risk factor for colon cancer (CC). However, how does the interplay between metabolic dysfunction caused by MS and its individual components affect CC microenvironment and prognosis remains unexplored. Angiogenesis and lymphangiogenesis are fundamental processes for tumor progression and dissemination, ensuring oxygen and nutrient delivery and supporting one of the most important pathways of tumor dissemination, contributing to metastasis. Thus, our aim was to evaluate whether the expression of molecular biomarkers involved in angiogenic and lymphangiogenic processes influenced CC clinicopathological features and prognosis in patients with MS. Clinical and pathological data of 300 patients submitted to CC surgical resection at a single tertiary hospital were retrospectively retrieved from hospital records. Tumor tissue microarrays of archived paraffin-embedded blocks were used to assess CD31, VEGF-A and D2–40 tissue expression by immunohistochemistry. The percentage of stained area was quantified by computerized morphometric analysis. No association between tissue expression of angiogenesis and lymphangiogenesis biomarkers and tumor clinical and pathological characteristics was found. However, in subgroup analysis of patients with MS, dysglycemia was associated with lower D2–40 expression (p = 0.007) and high waist-circumference was associated with higher D2–40 (p = 0.0029) and VEGF-A expression (p = 0.026). In an adjusted Cox proportional hazard model CD31 expression was significantly associated with greater disease-free survival (HR=0.62; 95% CI: 0.41–0.95, p = 0.028). No association was found between D2–40 and VEGF-A expression and CC prognosis. Our data reinforces previous reports that suggest the potential use of CD31 as a CC prognostic biomarker. Additionally, our data further supports the evidence for an interplay between metabolic dysfunction, tumor microenvironment, and vascularization pathways.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, A., Pereira, S. S., Brandão, J. R., Brochado, P., Monteiro, M. P., Araújo, A., & Faria, G. (2022). Colon tumor CD31 expression is associated with higher disease-free survival in patients with metabolic syndrome. Pathology - Research and Practice, 240, 154182. https://doi.org/10.1016/j.prp.2022.154182pt_PT
dc.identifier.doi10.1016/j.prp.2022.154182pt_PT
dc.identifier.eissn1618-0631
dc.identifier.issn0344-0338
dc.identifier.urihttp://hdl.handle.net/10400.22/22544
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0344033822004265?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectColon cancerpt_PT
dc.subjectAngiogenesispt_PT
dc.subjectLymphangiogenesispt_PT
dc.subjectMetabolic syndromept_PT
dc.subjectSurvivalpt_PT
dc.titleColon tumor CD31 expression is associated with higher disease-free survival in patients with metabolic syndromept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage7pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePathology - Research and Practicept_PT
oaire.citation.volume240pt_PT
person.familyNameSilva
person.givenNameAna Luisa
person.identifier.ciencia-id1213-5419-2294
person.identifier.orcid0000-0003-0880-2959
person.identifier.scopus-author-id57213535583
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc3853c6b-5e24-4d94-8bb2-8c7ecbb0b13b
relation.isAuthorOfPublication.latestForDiscoveryc3853c6b-5e24-4d94-8bb2-8c7ecbb0b13b

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