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Combination therapy with CD147‐targeted nanoparticles carrying phenformin decreases lung cancer growth

2023-07Research article Open access
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dc.contributor.authorPereira-Nunes, Andreia
dc.contributor.authorFerreira, Helena
dc.contributor.authorAbreu, Sara
dc.contributor.authorGuedes, Marta
dc.contributor.authorNeves, Nuno M.
dc.contributor.authorBaltazar, Fátima
dc.contributor.authorGranja, Sara
dc.contributor.authorGranja, Sara
dc.date.accessioned2025-11-21T16:33:14Z
dc.date.available2025-11-21T16:33:14Z
dc.date.issued2023-07
dc.description.abstractLung cancer is one of the most fatal cancers worldwide. Resistance to conventional therapies remains a hindrance to patient treatment. Therefore, the development of more effective anti-cancer therapeutic strategies is imperative. Solid tumors exhibit a hyperglycolytic phenotype, leading to enhanced lactate production; and, consequently, its extrusion to the tumor microenvironment. Previous data reveals that inhibition of CD147, the chaperone of lactate transporters (MCTs), decreases lactate export in lung cancer cells and sensitizes them to phenformin, leading to a drastic decrease in cell growth. In this study, the development of anti-CD147 targeted liposomes (LUVs) carrying phenformin is envisioned, and their efficacy is evaluated to eliminate lung cancer cells. Herein, the therapeutic effect of free phenformin and anti-CD147 antibody, as well as the efficacy of anti-CD147 LUVs carrying phenformin on A549, H292, and PC-9 cell growth, metabolism, and invasion, are evaluated. Data reveals that phenformin decreases 2D and 3D-cancer cell growth and that the anti-CD147 antibody reduces cell invasion. Importantly, anti-CD147 LUVs carrying phenformin are internalized by cancer cells and impaired lung cancer cell growth in vitro and in vivo. Overall, these results provide evidence for the effectiveness of anti-CD147 LUVs carrying phenformin in compromising lung cancer cell aggressiveness.por
dc.description.sponsorshipNORTE-01-0145-FEDER-000055 SFRH/BPD/117858/2016 and SFRH/BD/148476/2019
dc.identifier.citationPereira-Nunes, A., Ferreira, H., Abreu, S., Guedes, M., Neves, N. M., Baltazar, F., & Granja, S. (2023). Combination therapy with CD147‐targeted nanoparticles carrying phenformin decreases lung cancer growth. Advanced Biology, 7(7), 2300080. https://doi.org/10.1002/adbi.202300080
dc.identifier.doi10.1002/adbi.202300080
dc.identifier.eissn2701-0198
dc.identifier.urihttp://hdl.handle.net/10400.22/31020
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relationUIDB/50026/2020 and UIDP/50026/2020
dc.relation.hasversionhttps://advanced.onlinelibrary.wiley.com/doi/10.1002/adbi.202300080
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCD147
dc.subjectLung cancer
dc.titleCombination therapy with CD147‐targeted nanoparticles carrying phenformin decreases lung cancer growthpor
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.endPage12
oaire.citation.issue7
oaire.citation.startPage1
oaire.citation.titleAdvanced Biology
oaire.citation.volume7
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameGranja
person.givenNameSara
person.identifier.ciencia-idC41F-02E4-065E
person.identifier.orcid0000-0001-8717-6751
relation.isAuthorOfPublication06306a95-9c06-47c7-b2e5-5bbf757bec17
relation.isAuthorOfPublication.latestForDiscovery06306a95-9c06-47c7-b2e5-5bbf757bec17

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