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Impact of adiposity on staging and prognosis of colorectal cancer

2020Journal article Restricted access
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dc.contributor.authorSilva, Ana
dc.contributor.authorFaria, Gil
dc.contributor.authorAraújo, António
dc.contributor.authorMonteiro, Mariana P.
dc.date.accessioned2020-09-14T13:14:53Z
dc.date.available2020-09-14T13:14:53Z
dc.date.issued2020
dc.description.abstractAbdominal visceral fat is a well-recognized a risk for colorectal cancer (CRC). In contrast to the risk for CRC, the impact of adiposity in disease staging and patient survival is less well-established. Our aim was to critically review the literature on the influence of adiposity assessed by different methods routinely used in clinical settings, on CRC staging and prognosis. In the 32 studies reviewed, overweight was initially identified as a survival advantage, an evidence that was later challenged by studies suggesting that body adiposity is likely to have a deleterious effect in CRC outcomes, particularly in males. Hence, whether obesity has a negative impact in CRC staging or prognosis remains controversial. In sum, addressing the impact of body fat in CRC biological behavior is still an unmet need. Understanding how adiposity influences CRC staging and prognosis could allow further patient risk stratification for devising targeted interventions and improve clinical outcomes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.critrevonc.2019.102857pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/16265
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationMultidisciplinary Unit for Biomedical Resaerch
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1040842819302434?via%3Dihub#!pt_PT
dc.subjectBody Mass Indexpt_PT
dc.subjectIntra-Abdominal Fatpt_PT
dc.subjectObesitypt_PT
dc.subjectPrognosispt_PT
dc.subjectAdipositypt_PT
dc.subjectColorectal Neoplasmspt_PT
dc.subjectNeoplasm Stagingpt_PT
dc.titleImpact of adiposity on staging and prognosis of colorectal cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMultidisciplinary Unit for Biomedical Resaerch
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00215%2F2019/PT
oaire.citation.startPage102857pt_PT
oaire.citation.titleCritical Reviews in Oncology/Hematologypt_PT
oaire.citation.volume145pt_PT
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationbe4707dc-814f-4b63-bb5b-2b15d3f5a0a6
relation.isProjectOfPublication.latestForDiscoverybe4707dc-814f-4b63-bb5b-2b15d3f5a0a6

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