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Unraveling the role of metals and organic acids in bacterial antimicrobial resistance in the food chain

2023-09-21Journal article Open access
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dc.contributor.authorRebelo, Andreia
dc.contributor.authorAlmeida, Agostinho
dc.contributor.authorPeixe, Luísa
dc.contributor.authorAntunes, Patrícia
dc.contributor.authorNovais, Carla
dc.date.accessioned2024-12-16T15:37:31Z
dc.date.available2024-12-16T15:37:31Z
dc.date.issued2023-09-21
dc.description.abstractAntimicrobial resistance (AMR) has a significant impact on human, animal, and environmental health, being spread in diverse settings. Antibiotic misuse and overuse in the food chain are widely recognized as primary drivers of antibiotic-resistant bacteria. However, other antimicrobials, such as metals and organic acids, commonly present in agri-food environments (e.g., in feed, biocides, or as long-term pollutants), may also contribute to this global public health problem, although this remains a debatable topic owing to limited data. This review aims to provide insights into the current role of metals (i.e., copper, arsenic, and mercury) and organic acids in the emergence and spread of AMR in the food chain. Based on a thorough literature review, this study adopts a unique integrative approach, analyzing in detail the known antimicrobial mechanisms of metals and organic acids, as well as the molecular adaptive tolerance strategies developed by diverse bacteria to overcome their action. Additionally, the interplay between the tolerance to metals or organic acids and AMR is explored, with particular focus on co-selection events. Through a comprehensive analysis, this review highlights potential silent drivers of AMR within the food chain and the need for further research at molecular and epidemiological levels across different food contexts worldwide.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRebelo, A., Almeida, A., Peixe, L., Antunes, P., & Novais, C. (2023). Unraveling the role of metals and organic acids in bacterial antimicrobial resistance in the food chain. Antibiotics, 12(9), Artigo 9. https://doi.org/10.3390/antibiotics12091474pt_PT
dc.identifier.doi10.3390/antibiotics12091474pt_PT
dc.identifier.eissn2079-6382
dc.identifier.urihttp://hdl.handle.net/10400.22/26870
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationThis study was financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences—UCIBIO, the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB, by the AgriFood XXI I&D&I project (NORTE-01-0145-FEDER-000041) co-financed by the European Regional Development Fund (ERDF), and through the NORTE 2020 (Programa Operacional Regional do Norte 2014/2020). Andreia Rebelo was supported by a PhD fellowship from FCT (SFRH/BD/137100/2018), co-financed by the European Social Fund through the Norte Portugal Regional Operational Program (NORTE 2020).pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2079-6382/12/9/1474pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCopperpt_PT
dc.subjectMercurypt_PT
dc.subjectArsenicpt_PT
dc.subjectOrganic acidspt_PT
dc.subjectAntibiotic resistancept_PT
dc.subjectFood safetypt_PT
dc.titleUnraveling the role of metals and organic acids in bacterial antimicrobial resistance in the food chainpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleAntibioticspt_PT
oaire.citation.volume12(9)pt_PT
person.familyNameRebelo
person.givenNameAndreia
person.identifier.ciencia-idA81C-7A59-ECAD
person.identifier.orcid0000-0003-2218-6005
person.identifier.ridT-9024-2017
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication913dc5cd-9e92-456d-88f5-419571a87f85
relation.isAuthorOfPublication.latestForDiscovery913dc5cd-9e92-456d-88f5-419571a87f85

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