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Spectral Optical Properties of Rabbit Brain Cortex between 200 and 1000 nm

2021Journal article Open access
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dc.contributor.authorGonçalves, Tânia M.
dc.contributor.authorMartins, Inês
dc.contributor.authorSilva, Hugo
dc.contributor.authorTuchin, Valery V.
dc.contributor.authorOliveira, Luís
dc.date.accessioned2022-02-11T10:42:47Z
dc.date.available2022-02-11T10:42:47Z
dc.date.issued2021
dc.description.abstractThe knowledge of the optical properties of biological tissues in a wide spectral range is highly important for the development of noninvasive diagnostic or treatment procedures. The absorption coefficient is one of those properties, from which various information about tissue components can be retrieved. Using transmittance and reflectance spectral measurements acquired from ex vivo rabbit brain cortex samples allowed to calculate its optical properties in the ultraviolet to the near infrared spectral range. Melanin and lipofuscin, the two pigments that are related to the aging of tissues and cells were identified in the cortex absorption. By subtracting the absorption of these pigments from the absorption of the brain cortex, it was possible to evaluate the true ratios for the DNA/RNA and hemoglobin bands in the cortex—12.33-fold (at 260 nm), 12.02-fold (at 411 nm) and 4.47-fold (at 555 nm). Since melanin and lipofuscin accumulation increases with the aging of the brain tissues and are related to the degeneration of neurons and their death, further studies should be performed to evaluate the evolution of pigment accumulation in the brain, so that new optical methods can be developed to aid in the diagnosis and monitoring of brain diseases.pt_PT
dc.description.sponsorshipThe work of L.M.O. was supported by the Portuguese Science Foundation, Grant No. FCT-UIDB/04730/2020. The work of V.V.T. was supported by the Government of the Russian Federation (project No. 075-15-2019-1885 to support scientific research projects implemented under the supervision of leading scientists at Russian institutions, Russian institutions of higher education).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGonçalves, T.M., Martins, I.S., Silva, H.F., Tuchin, V.V., Oliveira, L.M. Spectral optical properties of rabbit brain cortex between 200 and 1000 nm. Photochem, vol. 1, no. 2, 190-208.pt_PT
dc.identifier.doi10.3390/photochem1020011pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/19915
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationFCT-UIDB/04730/2020pt_PT
dc.relation075-15-2019-1885pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2673-7256/1/2/11pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTissue spectroscopypt_PT
dc.subjectTissue optical propertiespt_PT
dc.subjectScattering coefficientpt_PT
dc.subjectAbsorption coefficientpt_PT
dc.subjectDNA contentpt_PT
dc.subjectBlood contentpt_PT
dc.subjectPigment detectionpt_PT
dc.titleSpectral Optical Properties of Rabbit Brain Cortex between 200 and 1000 nmpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage208pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage190pt_PT
oaire.citation.titlePhotochempt_PT
oaire.citation.volume1pt_PT
person.familyNameMartins
person.familyNameDias Silva
person.familyNameOliveira
person.givenNameInês
person.givenNameHugo Filipe
person.givenNameLuís
person.identifier414820
person.identifier.ciencia-idEA11-E3A6-12CB
person.identifier.ciencia-idC312-F342-BD23
person.identifier.orcid0000-0003-2876-3686
person.identifier.orcid0000-0002-6065-4335
person.identifier.orcid0000-0003-0667-3428
person.identifier.ridB-7198-2017
person.identifier.scopus-author-id55853723900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb92cdee2-1e37-46f7-b392-4739075f273d
relation.isAuthorOfPublication8e49fbcc-e221-4c7a-aac3-48a2bba5d53a
relation.isAuthorOfPublication4e2de4d7-142a-400f-8dbf-cd0ff9551093
relation.isAuthorOfPublication.latestForDiscovery8e49fbcc-e221-4c7a-aac3-48a2bba5d53a

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