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Orientador(es)
Resumo(s)
Molecular imprinting polymers (MIP) have been
applied to capture and stabilize complex protein matrices at
plasmonic sensor surfaces. Ultrathin MIP layers at the surface of
gold nanodisks enable the label free quantification of global
interactions of polyphenols with protein mixtures. Separate
polyphenols (catechin, procyanidin B3- catechin dimer, and
PGG-pentagalloyl glucose) give specific and different binding
levels to the MIP supported saliva plasmonic sensor. The
demonstrated biosensor has application to study bioavailability of
polyphenols or evaluation of local retention of small drug
molecules.
Descrição
Palavras-chave
Localized surface plasmon resonance (LSPR) Molecular imprinting Complex protein matrix Polyphenols Biosensing Nanodisks
Contexto Educativo
Citação
Editora
American Chemical Society