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Boosting cosmeceutical peptides: coupling imidazolium-based ionic liquids to pentapeptide-4 originates new leads with antimicrobial and collagenesis-inducing activities

2022-08-11Journal article Restricted access
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dc.contributor.authorGomes, Ana
dc.contributor.authorBessa, Lucinda J.
dc.contributor.authorFernandes, Iva
dc.contributor.authorAguiar, Luísa
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorMonteiro, Cláudia
dc.contributor.authorMartins, M. Cristina L.
dc.contributor.authorMateus, Nuno
dc.contributor.authorGameiro, Paula
dc.contributor.authorTeixeira, Cátia
dc.contributor.authorGomes, Paula
dc.date.accessioned2022-12-13T18:11:23Z
dc.date.available2022-12-13T18:11:23Z
dc.date.issued2022-08-11
dc.description.abstractFollowing our previous reports on dual-action antibacterial and collagenesis-inducing hybrid peptide constructs based on “pentapeptide-4” (PP4, with amino acid sequence KTTKS), whose N-palmitoyl derivative is the well-known cosmeceutical ingredient Matrixyl, herein we disclose novel ionic liquid/PP4 conjugates (IL-KTTKS). These conjugates present potent activity against either antibiotic-susceptible strains or multidrug resistant clinical isolates of both Gram-positive and Gram-negative bacterial species belonging to the so-called “ESKAPE” group of pathogens. Noteworthy, their antibacterial activity is preserved in simulated wound fluid, which anticipates an effective action in the setting of a real wound bed. Moreover, their collagenesis-inducing effects in vitro are comparable to or stronger than those of Matrixyl. Altogether, IL-KTTKS exert a triple antibacterial, antifungal, and collagenesis-inducing action in vitro. These findings provide solid grounds for us to advance IL-KTTKS conjugates as promising leads for future development of topical treatments for complicated skin and soft tissue infections (cSSTI). Further studies are envisaged to incorporate IL-conjugates into suitable nanoformulations, to reduce toxicity and/or improve resistance to proteolytic degradation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGomes, A., Bessa, L. J., Fernandes, I., Aguiar, L., Ferraz, R., Monteiro, C., Martins, M. C. L., Mateus, N., Gameiro, P., Teixeira, C., & Gomes, P. (2022). Boosting Cosmeceutical Peptides: Coupling Imidazolium-Based Ionic Liquids to Pentapeptide-4 Originates New Leads with Antimicrobial and Collagenesis-Inducing Activities. Microbiology Spectrum, 10(4), e02291-02221. https://doi.org/doi:10.1128/spectrum.02291-21pt_PT
dc.identifier.doihttps://doi.org/10.1128/spectrum.02291-21pt_PT
dc.identifier.eissn2165-0497
dc.identifier.urihttp://hdl.handle.net/10400.22/21190
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherASM Journalspt_PT
dc.relation.publisherversionhttps://journals.asm.org/doi/10.1128/spectrum.02291-21pt_PT
dc.subjectAntibacterialpt_PT
dc.subjectAntifungalpt_PT
dc.subjectCollagenesis-inductionpt_PT
dc.subjectCosmeceutical peptidespt_PT
dc.subjectIonic liquidpt_PT
dc.subjectMatrixylpt_PT
dc.subjectAntimicrobial activitypt_PT
dc.subjectCollagen boostingpt_PT
dc.subjectPentapeptide-4pt_PT
dc.titleBoosting cosmeceutical peptides: coupling imidazolium-based ionic liquids to pentapeptide-4 originates new leads with antimicrobial and collagenesis-inducing activitiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage13pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMicrobiology Spectrumpt_PT
oaire.citation.volume10pt_PT
person.familyNameFerraz
person.givenNameRicardo
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.orcid0000-0002-1761-117X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication.latestForDiscoverya5a8faa7-12a5-4b1c-bced-44c895677397

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