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The endocannabinoid system may modulate sleep disorders in aging

2020Journal article Open access
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dc.contributor.authorMurillo-Rodríguez, Eric
dc.contributor.authorBudde, Henning
dc.contributor.authorVeras, André Barciela
dc.contributor.authorRocha, Nuno
dc.contributor.authorTelles-Correia, Diogo
dc.contributor.authorMonteiro, Diogo
dc.contributor.authorCid, Luis
dc.contributor.authorYamamoto, Tetsuya
dc.contributor.authorMachado, Sérgio
dc.contributor.authorTorterolo, Pablo
dc.date.accessioned2023-01-27T16:54:31Z
dc.date.available2023-01-27T16:54:31Z
dc.date.issued2020
dc.description.abstractAging is an inevitable process that involves changes across life in multiple neurochemical, neuroanatomical, hormonal systems, and many others. In addition, these biological modifications lead to an increase in age-related sickness such as cardiovascular diseases, osteoporosis, neurodegenerative disorders, and sleep disturbances, among others that affect activities of daily life. Demographic projections have demonstrated that aging will increase its worldwide rate in the coming years. The research on chronic diseases of the elderly is important to gain insights into this growing global burden. Novel therapeutic approaches aimed for treatment of age-related pathologies have included the endocannabinoid system as an effective tool since this biological system shows beneficial effects in preclinical models. However, and despite these advances, little has been addressed in the arena of the endocannabinoid system as an option for treating sleep disorders in aging since experimental evidence suggests that some elements of the endocannabinoid system modulate the sleep-wake cycle. This article addresses this less-studied field, focusing on the likely perspective of the implication of the endocannabinoid system in the regulation of sleep problems reported in the aged. We conclude that beneficial effects regarding the putative efficacy of the endocannabinoid system as therapeutic tools in aging is either inconclusive or still missing.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMurillo-Rodríguez, E., Budde, H., Veras, A. B., Rocha, N. B., Telles-Correia, D., Monteiro, D., Cid, L., Yamamoto, T., Machado, S., & Torterolo, P. (2020). The Endocannabinoid System May Modulate Sleep Disorders in Aging. Current neuropharmacology, 18(2), 97–108. https://doi.org/10.2174/1570159X17666190801155922pt_PT
dc.identifier.doi10.2174/1570159X17666190801155922pt_PT
dc.identifier.eissn1875-6190
dc.identifier.issn1570-159X
dc.identifier.urihttp://hdl.handle.net/10400.22/21967
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBentham Science Publisherspt_PT
dc.relation.publisherversionhttps://www.eurekaselect.com/article/100102pt_PT
dc.subjectCannabidiolpt_PT
dc.subjectChildhoodpt_PT
dc.subjectPharmacologypt_PT
dc.subjectSleeppt_PT
dc.subjectRapid eye movement sleeppt_PT
dc.subjectAgingpt_PT
dc.titleThe endocannabinoid system may modulate sleep disorders in agingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage108pt_PT
oaire.citation.startPage97pt_PT
oaire.citation.titleCurrent Neuropharmacologypt_PT
oaire.citation.volume18 (2)pt_PT
person.familyNameRocha
person.givenNameNuno
person.identifier192266
person.identifier.ciencia-idAE16-A494-5F8B
person.identifier.orcid0000-0002-3139-2786
person.identifier.ridM-9821-2013
person.identifier.scopus-author-id32867975300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9e940914-601a-4978-8d5b-74e5ade7ada7
relation.isAuthorOfPublication.latestForDiscovery9e940914-601a-4978-8d5b-74e5ade7ada7

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