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The impact of psychostimulants on central and peripheral neuro-immune regulation: a scoping review of cytokine profiles and their implications for addiction

2023-05-26Journal article Open access
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dc.contributor.authorBravo, Joana
dc.contributor.authorMagalhães, Catarina
dc.contributor.authorAndrade, Elva B.
dc.contributor.authorMagalhães, Ana
dc.contributor.authorSummavielle, Teresa
dc.date.accessioned2023-10-11T17:03:24Z
dc.date.available2023-10-11T17:03:24Z
dc.date.issued2023-05-26
dc.description.abstractIt is now well-accepted that psychostimulants act on glial cells causing neuroinflammation and adding to the neurotoxic effects of such substances. Neuroinflammation can be described as an inflammatory response, within the CNS, mediated through several cytokines, reactive oxygen species, chemokines and other inflammatory markers. These inflammatory players, in particular cytokines, play important roles. Several studies have demonstrated that psychostimulants impact on cytokine production and release, both centrally and at the peripheral level. Nevertheless, the available data is often contradictory. Because understanding how cytokines are modulated by psychoactive substances seems crucial to perspective successful therapeutic interventions, here, we conducted a scoping review of the available literature. We have focused on how different psychostimulants impact on the cytokine profile. Publications were grouped according to the substance addressed (methamphetamine, cocaine, methylphenidate, MDMA or other amphetamines), the type of exposure and period of evaluation (acute, short- or long-term exposure, withdrawal, and reinstatement). Studies were further divided in those addressing central cytokines, circulating (peripheral) levels, or both. Our analysis showed that the classical pro-inflammatory cytokines TNF-α, IL-6, and IL-1β were those more investigated. The majority of studies have reported increased levels of these cytokines in the central nervous system after acute or repeated drug. However, studies investigating cytokine levels during withdrawal or reinstatement have shown higher variability in their findings. Although we have identified fewer studies addressing circulating cytokines in humans, the available data suggest that the results may be more robust in animal models than in patients with problematic drug use. As a major conclusion, an extensive use of arrays for relevant cytokines should be considered to better determine which cytokines, upon the classical ones, may be involved in the progression from episodic use to the development of addiction. A concerted effort is still necessary to address the link between peripheral and central immune players, including from a longitudinal perspective. Until there, the identification of new biomarkers and therapeutic targets to envision personalized immune-based therapeutics will continue to be unlikely.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBravo, J., Magalhães, C., Andrade, E. B., Magalhães, A., & Summavielle, T. (2023). The impact of psychostimulants on central and peripheral neuro-immune regulation: A scoping review of cytokine profiles and their implications for addiction. Frontiers in Cellular Neuroscience, 17. https://www.frontiersin.org/articles/10.3389/fncel.2023.1109611pt_PT
dc.identifier.doi10.3389/fncel.2023.1109611pt_PT
dc.identifier.eissn1662-5102
dc.identifier.urihttp://hdl.handle.net/10400.22/23673
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationThis work was funded by National Funds through FCT— Fundação para a Ciência e a Tecnologia (FCT) in the framework of the project PTDC/SAU-TOX/0067/2021 and under the project UIDB/04293/2020. TS and EA employment contract were financed by national funds through FCT in the context of CEEC support (CEECINST/00123/2021, 2022.03699.CEECIND, and CEECIND/03675/2018). JB was supported by FCT PD/BD/135450/2017.pt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fncel.2023.1109611/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMethamphetaminept_PT
dc.subjectCocainept_PT
dc.subjectMethylphenidatept_PT
dc.subjectAmphetaminept_PT
dc.subjectAcute-usept_PT
dc.subjectChronic-usept_PT
dc.subjectWithdrawalpt_PT
dc.subjectReinstatementpt_PT
dc.titleThe impact of psychostimulants on central and peripheral neuro-immune regulation: a scoping review of cytokine profiles and their implications for addictionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage20pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Cellular Neurosciencept_PT
oaire.citation.volume17pt_PT
person.familyNameBravo
person.familyNameBonifácio Andrade
person.familyNameSummavielle
person.givenNameJoana
person.givenNameElva
person.givenNameTeresa
person.identifier677706
person.identifier.ciencia-idAA15-F362-062E
person.identifier.ciencia-id511C-11AA-7980
person.identifier.ciencia-idC41E-0816-5C85
person.identifier.orcid0000-0002-8403-7235
person.identifier.orcid0000-0002-1941-580X
person.identifier.orcid0000-0003-2548-6281
person.identifier.ridC-9776-2012
person.identifier.scopus-author-id6603092949
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication617f0f54-58dd-45b8-a90f-177187cd197e
relation.isAuthorOfPublicatione3b8883f-57b2-4b83-afa1-88e663ed8d1f
relation.isAuthorOfPublication207ee2de-85a0-4144-9e7e-b376c600e065
relation.isAuthorOfPublication.latestForDiscovery617f0f54-58dd-45b8-a90f-177187cd197e

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