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Abstract(s)
Os Líquidos Iónicos (LIs) são sais orgânicos, cujo ponto de fusão é inferior a 100ºC. Estes compostos têm sido alvo de uma ampla investigação, uma vez que, possuem diversas características físicas, químicas e biológicas interessantes e que podem ser ajustáveis. Estas características fazem com que seja possível a sua aplicação em diversas áreas, como a Química, Indústria Farmacêutica e a Biotecnologia. O presente trabalho tem como objetivo o estudo da atividade bacteriana e fúngica de líquidos iónicos baseados em beta-lactâmicos e fluroquinolonas, em que se pretende determinar se LIs baseados em fluroquinolonas e beta-lactâmicos terão atividade contra bactérias Gram-positivas e Gram-negativas, resistentes e sensíveis e ainda um modelo de levedura.
Este trabalho vai avaliar também o estudo da viabilidade/proliferação de determinados LIs nas linhas celulares RKO (neoplasia do cólon), T47D (neoplasia da mama), MG63 (neoplasia do osso), A459 (neoplasia do pulmão), Hep62 (neoplasia do fígado) e fibroblastos e ainda compreender o modo de atuação das vias de sinalização nos líquidos iónicos em estudo e nas linhas celulares RKO (neoplasia do cólon), T47D (neoplasia da mama), MG63 (neoplasia do osso), A459 (neoplasia do pulmão), Hep62 (neoplasia do fígado) e fibroblastos.
No estudo da atividade bacteriana, os LIs irão ser aplicados em estirpes bacterianas, nas quais estarão incluídas algumas estirpes resistentes. Os resultados obtidos no presente trabalho destacam o potencial destes compostos como novos fármacos, e a importância de outros estudos para compreender os mecanismos pelos quais eles atuam, tanto em células como em bactérias ou em fungos.
Ionic Liquids (ILs) are organic salts whose melting point is below 100° C. These compounds have been he subject of extensive research since they have physical, chemical and biological charcateristics that can be adjustable. These characteristics make it posisble to be applied in several areas, such as Chemistry, Pharmaceutical Industry and Biotechnology. The aim of the presente work is to study the bacterial and fungal activity of ionic liquids based on beta-lactams and quinolones. I tis intended to determine if L1s based on quinolones and beta-lactams will have activity against Gram-positive and Gram-negative, resistant and sensitive bactéria and still a modelo of yeast. This work will also evaluate the viability/proliferation of certain ionic liquids in the RKO (colon cancer), T47D (breast cancer), MG63 (bone cancer), A459 (lung cancer), Hep 62 (liver cancer) and fibroblastos, and also to understand the mode of action of the signaling pathways in the ionic liquids in the RKO (colon neoplasia), T47D (breast neoplasia), MG63 (bone neoplasia), A459 (lung neoplasia), Hep62 (liver neoplasm) and fibroblastos. In the study of bacterial activity, the Ionic Liquids will be applied in bacterial strains, in which some resistant strains will be inclued. The results obtained in the presente work highlight the potential of these compounds as new drugs, and the importance of other studies to understand the mechanisms by which they act, both in cells and in bactéria or fungi.
Ionic Liquids (ILs) are organic salts whose melting point is below 100° C. These compounds have been he subject of extensive research since they have physical, chemical and biological charcateristics that can be adjustable. These characteristics make it posisble to be applied in several areas, such as Chemistry, Pharmaceutical Industry and Biotechnology. The aim of the presente work is to study the bacterial and fungal activity of ionic liquids based on beta-lactams and quinolones. I tis intended to determine if L1s based on quinolones and beta-lactams will have activity against Gram-positive and Gram-negative, resistant and sensitive bactéria and still a modelo of yeast. This work will also evaluate the viability/proliferation of certain ionic liquids in the RKO (colon cancer), T47D (breast cancer), MG63 (bone cancer), A459 (lung cancer), Hep 62 (liver cancer) and fibroblastos, and also to understand the mode of action of the signaling pathways in the ionic liquids in the RKO (colon neoplasia), T47D (breast neoplasia), MG63 (bone neoplasia), A459 (lung neoplasia), Hep62 (liver neoplasm) and fibroblastos. In the study of bacterial activity, the Ionic Liquids will be applied in bacterial strains, in which some resistant strains will be inclued. The results obtained in the presente work highlight the potential of these compounds as new drugs, and the importance of other studies to understand the mechanisms by which they act, both in cells and in bactéria or fungi.
Description
Keywords
Líquido iónico Atividade bacteriana Neoplasia