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Self-powered biosensor towards glucose diagnostic in Point-of-Care

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dc.contributor.authorVinagre, Inês
dc.contributor.authorAlves, Joaquim
dc.contributor.authorMoreira, Felismina T.C.
dc.date.accessioned2024-11-08T15:52:23Z
dc.date.available2024-11-08T15:52:23Z
dc.date.issued2024
dc.description.abstractMonitoring blood glucose levels is of great importance, especially for people at high risk of developing diabetes. To this end, an innovative biosensor device has been developed that uses a miniaturized and membraneless enzymatic fuel cell (EFC) as an electrical reader box for diabetes diagnosis at the point-of-care. Gold screen-printed electrodes (Au-SPE) were modified with the enzyme glucose oxidase (GOx), which is used as a glucose-consuming biocatalyst at both the anode and the cathode of the EFC. The enzyme was immobilized in a cathode based on graphene oxide/prussian blue nanocubes (GO/PBNCs) and in an anode based on a biographene layer. Hydrogen peroxide, a product of the enzymatic conversion of glucose, was electrocatalytically reduced by using PBNCs at the cathode. In parallel, glucose oxidation catalyzed by oxygen-mediated glucose oxidase took place at the anode. The analytical performance was evaluated separately for both electrode systems. The combination of the two electrodes resulted in an EFC with an output power for glucose of 5 mM (close to physiological conditions) of approximately (1.8 μW/ cm −2). This proposed self-powered biosensor opens the door for a fully autonomous biosensor device that can be used for any target analyte at room temperature and using the oxygen present in the air, thus enabling diagnosis anywhere.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.citationVinagre, I., Alves, J., & Moreira, F.T.C. (2024, Apr. 17-18). Self-powered biosensor towards glucose diagnostic in Point-of-Care [Abstract]. POCT Meeting 2024: Innovations from assays, microfluidics to production, Leipzig, Germanypt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/26374
dc.language.isoengpt_PT
dc.subjectEnzymatic Fuel Cell,pt_PT
dc.subjectGlucose oxidase,pt_PT
dc.subjectGlucosept_PT
dc.subjectBiographenept_PT
dc.subjectPrussian blue Nanocubes.pt_PT
dc.titleSelf-powered biosensor towards glucose diagnostic in Point-of-Carept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLeipzig, Germanypt_PT
oaire.citation.titlePOCT Meeting 2024: Innovations from assays, microfluidics to productionpt_PT
person.familyNameMoreira
person.givenNameFelismina
person.identifier1589429
person.identifier.ciencia-idC917-6A46-A270
person.identifier.orcid0000-0003-4237-8952
person.identifier.scopus-author-id23486193000
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication9c13153d-a73a-49ff-b7f6-c9733bc6725e
relation.isAuthorOfPublication.latestForDiscovery9c13153d-a73a-49ff-b7f6-c9733bc6725e

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