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Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

dc.contributor.authorNasuti, Cinzia
dc.contributor.authorCarloni, Manuel
dc.contributor.authorFedeli, Donatella
dc.contributor.authorGabbianelli, Rosita
dc.contributor.authorDi Stefano, Antonio
dc.contributor.authorCerasa, Laura Serafina
dc.contributor.authorSilva, Isabel
dc.contributor.authorDomingues, Valentina F.
dc.contributor.authorCiccocioppo, Roberto
dc.date.accessioned2014-01-17T09:42:54Z
dc.date.available2014-01-17T09:42:54Z
dc.date.issued2013
dc.description.abstractPesticide exposure during brain development could represent an important risk factor for the onset of neurodegenerative diseases. Previous studies investigated the effect of permethrin (PERM) administered at 34 mg/kg, a dose close to the no observable adverse effect level (NOAEL) from post natal day (PND) 6 to PND 21 in rats. Despite the PERM dose did not elicited overt signs of toxicity (i.e. normal body weight gain curve), it was able to induce striatal neurodegeneration (dopamine and Nurr1 reduction, and lipid peroxidation increase). The present study was designed to characterize the cognitive deficits in the current animal model. When during late adulthood PERM treated rats were tested for spatial working memory performances in a T-maze-rewarded alternation task they took longer to choose for the correct arm in comparison to age matched controls. No differences between groups were found in anxiety-like state, locomotor activity, feeding behavior and spatial orientation task. Our findings showing a selective effect of PERM treatment on the T-maze task point to an involvement of frontal cortico-striatal circuitry rather than to a role for the hippocampus. The predominant disturbances concern the dopamine (DA) depletion in the striatum and, the serotonin (5-HT) and noradrenaline (NE) unbalance together with a hypometabolic state in the medial prefrontal cortex area. In the hippocampus, an increase of NE and a decrease of DA were observed in PERM treated rats as compared to controls. The concentration of the most representative marker for pyrethroid exposure (3-phenoxybenzoic acid) measured in the urine of rodents 12 h after the last treatment was 41.50 µ/L and it was completely eliminated after 96 h.por
dc.identifier.doi10.1016/j.tox.2012.09.016pt_PT
dc.identifier.issn0300-483X/$
dc.identifier.urihttp://hdl.handle.net/10400.22/3334
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.ispartofseriesToxicology; Vol. 303
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0300483X12003721por
dc.subjectRatpor
dc.subjectPermethrinpor
dc.subjectEarly life exposurepor
dc.subject3-Phenoxybenzoic acidpor
dc.subjectSpatial working memorypor
dc.subjectT-mazepor
dc.subjectMonoaminespor
dc.titleEffects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent ratspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage168por
oaire.citation.startPage162por
oaire.citation.titleToxicologypor
oaire.citation.volume303por
person.familyNameDomingues
person.givenNameValentina Maria Fernandes
person.identifier.ciencia-id4E16-791D-6664
person.identifier.orcid0000-0003-3472-849X
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationbe653ab6-34ec-4329-972a-eee990a7ec66
relation.isAuthorOfPublication.latestForDiscoverybe653ab6-34ec-4329-972a-eee990a7ec66

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