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Response surface methodology applied to SPE for the determination of ibuprofen in various types of water samples
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Orientador(es)
Resumo(s)
Over the last few years, there has been a growing concern about the presence of pharmaceuticals
in the environment. The main objective of this study was to develop and validate
an SPE method using surface response methodology for the determination of ibuprofen
in different types of water samples. The influence of sample pH and sample volume on
the ibuprofen recovery was studied. The effect of each studied independent variable is
pronounced on the dependent variable (ibuprofen recovery). Good selectivity, extraction efficiency,
and precision were achieved using 600 mL of sample volume with the pH adjusted
to 2.2. LC with fluorescence detection was employed. The optimized method was applied to
20 water samples from the North and South of Portugal.
Descrição
Palavras-chave
Ibuprofen Response Surface Methodology SPE Water samples
Contexto Educativo
Citação
Editora
WILEY-VCH Verlag