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Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria

2013-11-06Journal article Open access
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dc.contributor.authorFerraz, Ricardo
dc.contributor.authorTeixeira, Vânia
dc.contributor.authorRodrigues, Débora
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorFernandes, Rúben
dc.contributor.authorNoronha, João Paulo
dc.contributor.authorPetrovski, Zeljko
dc.contributor.authorBranco, Luís
dc.date.accessioned2015-01-29T16:48:51Z
dc.date.available2015-01-29T16:48:51Z
dc.date.issued2013-11-06
dc.description.abstractAntibacterial activity of novel Active Pharmaceutical Ingredient Ionic Liquids (API-ILs) based on ampicillin anion [Amp] have been evaluated. They showed growth inhibition and bactericidal properties on some sensitive bacteria and especially some Gram-negative resistant bacteria when compared to the [Na][Amp] and the initial bromide and chloride salts. For these studies were analysed the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBIC) against sensitive Gram-negative bacteria Escherichia coli ATCC 25922 and Klebsiella pneumonia (clinically isolated), as well as sensitive Gram positive S. Aureus ATCC 25923, Staphylococcus epidermidis and Enterococcus faecalis and completed using clinically isolated resistent strains: E. coli TEM CTX M9, E. coli CTX M2 and E. coli AmpC Mox. From the obtained MIC values of studied APIs-ILs and standard [Na][Amp] were derived RDIC values (relative decrease of inhibitory concentration). High RDIC values of [C16Pyr][Amp] especially against two resistant Gram-negative strains E. coli TEM CTX M9 (RDIC>1000) and E. coli CTX M2 (RDIC>100) point clearly to a potential promising role of APIs-ILs as antimicrobial drugs especially against resistant bacterial strains.por
dc.identifier.doi10.1039/c3ra44286a
dc.identifier.urihttp://hdl.handle.net/10400.22/5525
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherRoyal Society of Chemistrypor
dc.titleAntibacterial activity of Ionic Liquids based on ampicillin against resistant bacteriapor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleRSC Advancespor
person.familyNameFerraz
person.familyNamePrudêncio
person.familyNameFernandes
person.givenNameRicardo
person.givenNameCristina
person.givenNameRúben
person.identifier1200571
person.identifier635792
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.ciencia-id0D1F-4090-E82A
person.identifier.orcid0000-0002-1761-117X
person.identifier.orcid0000-0002-9920-936X
person.identifier.orcid0000-0001-8933-3984
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
person.identifier.scopus-author-id6508057930
person.identifier.scopus-author-id57640135700
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isAuthorOfPublication9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4
relation.isAuthorOfPublication.latestForDiscovery9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4

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