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A preliminary assessment of a stool-based microRNA profile for early colorectal cancer screening

2025-08-05Research article Open access
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dc.contributor.authorSantos, Daniela A. R.
dc.contributor.authorEiras, Mariana
dc.contributor.authorGonzalez-Santos, Miguel
dc.contributor.authorSantos, Marlene
dc.contributor.authorPereira, Carina
dc.contributor.authorSantos, Lúcio Lara
dc.contributor.authorDinis-Ribeiro, Mário
dc.contributor.authorLima, Luís
dc.contributor.authorSantos, Marlene
dc.date.accessioned2025-10-17T10:03:16Z
dc.date.available2025-10-17T10:03:16Z
dc.date.issued2025-08-05
dc.description.abstractColorectal cancer screening methods are well established worldwide as a fundamental pilar in CRC management, namely through non-invasive faecal occult blood testing. However, the limited sensitivity of faecal occult blood test for detecting precancerous lesions highlights the need to search for alternative tools, such as microRNAs (miRs). The main aim of this study was to identify stoolbased miR profiles for early colorectal cancer detection. A panel with miR-21-5p, miR-199a-5p, and age showed a moderate performance for colorectal cancer detection (sensitivity: 88%). Additionally, miR-451a, miR-21-5p, miR-199a-5p, age, and gender showed high performance for discriminating high-grade dysplasia lesions (sensitivity: 91%). Moreover, when we obtained a positive result in either panel, we achieved a sensitivity of 96% for high-grade dysplasia lesions identification. Finally, when a negative result was obtained in these panels after a positive faecal occult blood test result, we accurately identified individuals without lesions. These findings demonstrate the potential of miR panels as non-invasive biomarkers for colorectal cancer and high-grade dysplasia lesions detection and could constitute a secondary screening method following a positive faecal occult blood test.por
dc.identifier.citationSantos, D. A. R., Eiras, M., Gonzalez-Santos, M., Santos, M., Pereira, C., Santos, L. L., Dinis-Ribeiro, M., & Lima, L. (2025). A preliminary assessment of a stool-based microRNA profile for early colorectal cancer screening. Scientific Reports, 15(1), 28597. https://doi.org/10.1038/s41598-025-14485-z
dc.identifier.doi10.1038/s41598-025-14485-z
dc.identifier.eissn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.22/30630
dc.language.isoeng
dc.peerreviewedyes
dc.publisherNature Briefing
dc.relation.hasversionhttps://www.nature.com/articles/s41598-025-14485-z
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectColorectal cancer
dc.subjectCRC management
dc.titleA preliminary assessment of a stool-based microRNA profile for early colorectal cancer screeningpor
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.titleScientific Reports
oaire.citation.volume15
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSantos
person.givenNameMarlene
person.identifier1508370
person.identifier.ciencia-id8311-B967-31C4
person.identifier.orcid0000-0001-5020-5942
person.identifier.scopus-author-id57110502000
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublication.latestForDiscovery8ce9ee39-a4c6-46ae-99e2-49397b550f1b

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