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Sample preparation and chromatographic methods for the determination of protein-bound uremic retention solutes in human biological samples: An overview

2023-01-15Journal article Restricted access
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dc.contributor.authorFernandes, Sara R.
dc.contributor.authorMeireles, Andreia N.
dc.contributor.authorMarques, Sara S.
dc.contributor.authorSilva, Luís
dc.contributor.authorBarreiros, Luisa
dc.contributor.authorSampaio-Maia, Benedita
dc.contributor.authorMiro, Manuel
dc.contributor.authorSegundo, Marcela A.
dc.date.accessioned2023-04-12T15:18:42Z
dc.date.available2023-04-12T15:18:42Z
dc.date.issued2023-01-15
dc.description.abstractProtein-bound uremic retention solutes, such as indole-3-acetic acid, indoxyl sulfate, p-cresol and p-cresol sulfate, are associated with the development of several pathologies, namely renal, cardiovascular, and bone toxicities, due to their potential accumulation in the human body, thus requiring analytical methods for monitoring and evaluation. The present review addresses conventional and advanced sample treatment procedures for sample handling and the chromatographic analytical methods developed for quantification of these compounds in different biological fluids, with particular focus on plasma, serum, and urine. The sample preparation and chromatographic methods coupled to different detection systems are critically discussed, focusing on the different steps involved for sample treatment, namely elimination of interfering compounds present in the sample matrix, and the evaluation of their environmental impact through the AGREEprep tool. There is a clear trend for the application of liquid-chromatography coupled to tandem mass spectrometry, which requires protein precipitation, solid-phase extraction and/or dilution prior to analysis of biological samples. Furthermore, from a sustainability point of view, miniaturized methods resorting to microplate devices are highly recommended.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFernandes, S. R., Meireles, A. N., Marques, S. S., Silva, L., Barreiros, L., Sampaio-Maia, B., Miró, M., & Segundo, M. A. (2023). Sample preparation and chromatographic methods for the determination of protein-bound uremic retention solutes in human biological samples: An overview. Journal of Chromatography B, 1215, 123578. https://doi.org/10.1016/j.jchromb.2022.123578pt_PT
dc.identifier.doi10.1016/j.jchromb.2022.123578pt_PT
dc.identifier.eissn1873-376X
dc.identifier.issn0378-4347
dc.identifier.urihttp://hdl.handle.net/10400.22/22715
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1570023222004834?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectProtein-bound compoundspt_PT
dc.subjectp-Cresolpt_PT
dc.subjectp-Cresol sulfatept_PT
dc.subjectIndoxyl sulfatept_PT
dc.subjectIndole-3-acetic acidpt_PT
dc.subjectBiological samplespt_PT
dc.titleSample preparation and chromatographic methods for the determination of protein-bound uremic retention solutes in human biological samples: An overviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage12pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Chromatography Bpt_PT
oaire.citation.volume1215pt_PT
person.familyNameFernandes
person.familyNameBarreiros
person.givenNameSara
person.givenNameLuisa
person.identifier.ciencia-id1C12-D800-38A4
person.identifier.ciencia-id611F-E0C5-0230
person.identifier.orcid0000-0001-7042-1941
person.identifier.orcid0000-0003-3481-5809
person.identifier.ridD-7950-2013
person.identifier.scopus-author-id57203278917
person.identifier.scopus-author-id6508205485
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication6c2ed5f0-c3fd-4559-99a3-b8d78d019b47
relation.isAuthorOfPublication1e66bacc-64de-4ecb-96b7-4c0e366cba57
relation.isAuthorOfPublication.latestForDiscovery6c2ed5f0-c3fd-4559-99a3-b8d78d019b47

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