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Exploratory behavior in rats postnatally exposed to cocaine and housed in an enriched environment

2008-10-06Journal article Restricted access
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dc.contributor.authorMagalhães, Ana
dc.contributor.authorMelo, Pedro
dc.contributor.authorAlves, Cecília Juliana
dc.contributor.authorTavares, Maria Amélia
dc.contributor.authorSousa, Liliana De
dc.contributor.authorSummavielle, Teresa
dc.date.accessioned2022-06-02T15:13:49Z
dc.date.available2022-06-02T15:13:49Z
dc.date.issued2008-10-06
dc.description.abstractExposure to cocaine in early periods of postnatal life is usually associated with changes in development of neurotransmitter systems and structure of the central nervous system. Such changes are most likely correlated with behavioral alterations. Environmental enrichment conditions (EC) in early stages is a factor that affects structural and behavioral development. The purpose of this study is to examine the effects of EC on rats postnatally exposed to cocaine on exploratory behavior. Wistar rats were as signed to four groups—Group 1: pups exposed to cocaine hydrochloride (15 mg/kg body weight/day) s.c., in two daily doses, from postnatal day (PND) 1 to 28 and reared in EC; Group 2: pups exposed to cocaine as previously described and reared in a stan dard environmental conditions (SC); Group 3: pups saline-injected and reared in EC; and Group 4: pups saline-injected and reared in SC. On PND 21, 24, and 28, groups of four rats (to reduce anxiety) were placed for 10 minutes into an arena with sev eral objects. The following exploratory behavioral categories were examined: object interaction, exploration, manipulation, approximation, and total time of object contact. Animals from Group 2 showed decreased object interaction and total contact on PND 21. Control offspring reared in EE showed decreases in exploratory behavior at all ages analyzed compared with the control SE group, while cocaine-exposed animals reared in EC showed decreased object interaction, object approximation, and total exploratory behavior. The results in this group suggest that EC improved information acquisition and memory processes in animals postnatally exposed to cocaine.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMagalhães, A., Melo, P., Alves, C. J., Tavares, M. A., De Sousa, L., & Summavielle, T. (2008). Exploratory Behavior in Rats Postnatally Exposed to Cocaine and Housed in an Enriched Environment. Annals of the New York Academy of Sciences, 1139(1), 358-365. https://doi.org/https://doi.org/10.1196/annals.1432.046pt_PT
dc.identifier.doi10.1196/annals.1432.046pt_PT
dc.identifier.eissn1749-6632
dc.identifier.issn0077-8923
dc.identifier.urihttp://hdl.handle.net/10400.22/20584
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNew York Academy of Sciencespt_PT
dc.relation.publisherversionhttps://nyaspubs.onlinelibrary.wiley.com/doi/10.1196/annals.1432.046pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectCocainept_PT
dc.subjectDevelopmentpt_PT
dc.subjectEnriched environmentpt_PT
dc.subjectSocial interactionspt_PT
dc.titleExploratory behavior in rats postnatally exposed to cocaine and housed in an enriched environmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage365pt_PT
oaire.citation.startPage358pt_PT
oaire.citation.titleANNALS of New York Academy of Sciencespt_PT
oaire.citation.volume1139pt_PT
person.familyNameSummavielle
person.givenNameTeresa
person.identifier677706
person.identifier.ciencia-idC41E-0816-5C85
person.identifier.orcid0000-0003-2548-6281
person.identifier.ridC-9776-2012
person.identifier.scopus-author-id6603092949
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication207ee2de-85a0-4144-9e7e-b376c600e065
relation.isAuthorOfPublication.latestForDiscovery207ee2de-85a0-4144-9e7e-b376c600e065

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