Repository logo
 
Publication

Prenatal exposure to cocaine and enriched environment

2006-09-06Journal article Open access
Simple item page
dc.contributor.authorMagalhães, Ana
dc.contributor.authorSummavielle, Teresa
dc.contributor.authorMelo, Pedro
dc.contributor.authorRosa, Rui
dc.contributor.authorTavares, Maria Amélia
dc.contributor.authorSousa, Liliana de
dc.date.accessioned2021-09-28T08:48:16Z
dc.date.available2021-09-28T08:48:16Z
dc.date.issued2006-09-06
dc.description.abstractExposure to cocaine throughout gestation may produce several deleterious outcomes in the offspring that include effects on neurotransmitter systems and structure of the central nervous system. Such changes are most likely correlated with behavioral alterations. Environmental enrichment (EE) in early stages is a factor that affects structural and behavioral development. This article examines the effects, upon social interactions, of EE during the first month of life in rats prenatally exposed to cocaine. Wistar dams were subcutaneously exposed to 60 mg/kg of cocaine divided in two daily doses from gestational day (GD)8 to GD22. Pair-fed controls were given saline vehicle in the same protocol. Offspring were distributed to the different environments in four experimental groups. Group 1: offspring from dams prenatally exposed to cocaine as previously described and reared in EE from postnatal day (PND)1 to PND28; Group 2: pups from cocaine-exposed dams and reared in a standard environment (SE); Group 3: pups from pair-fed saline-exposed dams and reared in EE; Group 4: offspring from saline-exposed dams and reared in SE. On PND21, 24, and 28, rats were examined in several social behavioral categories (play fighting, social investigation, comfort behaviors, and solicitation to play) for 10 min. Animals reared in SE do not display any differences due to treatment in the behavioral categories analyzed. Control offspring reared in EE presented decreased play fighting, decreased solicitation to play, and decreased social investigation compared to the control SE group, while cocaine-exposed animals reared in EE did not present these variations. These results suggest that EE rearing may unmask hidden effects of prenatal cocaine exposure.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMagalhães, A., Summavielle, T., Melo, P., Rosa, R., Tavares, M. A., & de Sousa, L. (2006). Prenatal exposure to cocaine and enriched environment. Annals of the New York Academy of Sciences, 1074(1), 620-631. https://doi.org/https://doi.org/10.1196/annals.1369.060pt_PT
dc.identifier.doi10.1196/annals.1369.060pt_PT
dc.identifier.issn1749-6632
dc.identifier.urihttp://hdl.handle.net/10400.22/18589
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttps://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1196/annals.1369.060pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCocainept_PT
dc.subjectDevelopmentpt_PT
dc.subjectEnriched environmentpt_PT
dc.subjectSocial interactionspt_PT
dc.titlePrenatal exposure to cocaine and enriched environmentpt_PT
dc.title.alternativeEffects on social interactionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceSatellite Meeting on Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity - Cocaine, GHB and Substituted Amphetaminespt_PT
oaire.citation.endPage631pt_PT
oaire.citation.startPage620pt_PT
oaire.citation.titleAnnals of the New York Academy of Sciencespt_PT
oaire.citation.volume1074pt_PT
person.familyNameSummavielle
person.familyNameMartins de Almeida Melo
person.givenNameTeresa
person.givenNamePedro Miguel
person.identifier677706
person.identifier.ciencia-idC41E-0816-5C85
person.identifier.ciencia-idCC17-D6DA-41CA
person.identifier.orcid0000-0003-2548-6281
person.identifier.orcid0000-0003-0590-0684
person.identifier.ridC-9776-2012
person.identifier.scopus-author-id6603092949
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication207ee2de-85a0-4144-9e7e-b376c600e065
relation.isAuthorOfPublicatione55c4fc5-819f-4b76-80ab-819cf3aa0037
relation.isAuthorOfPublication.latestForDiscoverye55c4fc5-819f-4b76-80ab-819cf3aa0037

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ART_Teresa Summavielle (2).pdf
Size:
212.76 KB
Format:
Adobe Portable Document Format
Download

Collections

ESS - CF - Artigos