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Extended-spectrum β-lactamases from the North of Portugal in the boundaries to Spain: emergence of high resistance to 4th generation cephalosporins

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dc.contributor.authorFernandes, Rúben
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorVieira, Mónica
dc.contributor.authorAmador, Paula
dc.contributor.authorBrito, Luísa
dc.contributor.authorCoelho, Pedro
dc.contributor.authorSilva, Nuno
dc.contributor.authorOliveira, C.
dc.contributor.authorPrudêncio, Cristina
dc.date.accessioned2013-04-15T12:52:52Z
dc.date.available2013-04-15T12:52:52Z
dc.date.issued2010
dc.description.abstractDuring the past 15 years, emergence and dissemination of third-generation cephalosporins resistance in nosocomial Enterobacteriaceae became a serious problem worldwide, due to the production of extended-spectrum-β-lactamases (ESBLs). The aim of this study was to investigate among the presence of ESBL-producing enterobacteria among Portuguese clinical isolates nearby Spain, to investigate the antimicrobial susceptibility patterns and to compare the two countries. The β-lactamases genes, blaTEM, blaSHV and blaCTX-M were detected by molecular methods. Among the ESBL-producing isolates it was found extraordinary levels (98.9%) of resistance to the fourth-generation cephalosporin Cefepime. These findings point to the need of reevaluate the definition of ESBL.en
dc.description.abstractNos últimos 15 anos, a emergência e disseminação da resistência das enterobactérias nosocomiais às cefalosporinas de teceira geração devido à produção de β-lactamases de espectro ampliado (ESBL) tem-se tornado uma preocupação a nível mundial. O objectivo deste estudo é determinar a presença de ESBL em isolados clínicos de enterobactérias, o perfil de susceptibilidade aos antimicrobianos e comparar a situação portuguesa com a espanhola. Os genes blaTEM, blaSHV e blaCTX-M das β-lactamases foram detectados por métodos moleculares. Nas estirpes portuguesas produtoras de ESBL foram detectados níveis preocupantes de resistência à Cefepima (4ª geração), 98,9%, levando-nos a questionar sobre a necessidade de redefinir ESBL.por
dc.identifier.isbn978-972-8688-69-1
dc.identifier.urihttp://hdl.handle.net/10400.22/1294
dc.language.isoengen
dc.peerreviewedyesen
dc.publisherInstituto Politécnico do Porto. Escola Superior de Tecnologia da Saúde do Porto - Politemapor
dc.titleExtended-spectrum β-lactamases from the North of Portugal in the boundaries to Spain: emergence of high resistance to 4th generation cephalosporinspor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.titleI Congresso Internacional da Saúde Gaia-Portopor
person.familyNameFernandes
person.familyNameFerraz
person.familyNameVieira
person.familyNameCoelho
person.familyNamePrudêncio
person.givenNameRúben
person.givenNameRicardo
person.givenNameMónica
person.givenNamePedro
person.givenNameCristina
person.identifier635792
person.identifier1200571
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person.identifier.orcid0000-0001-8933-3984
person.identifier.orcid0000-0002-1761-117X
person.identifier.orcid0000-0002-9614-9031
person.identifier.orcid0000-0002-2343-1108
person.identifier.orcid0000-0002-9920-936X
person.identifier.ridG-5639-2011
person.identifier.ridD-8977-2016
person.identifier.ridAAZ-9239-2020
person.identifier.scopus-author-id57640135700
person.identifier.scopus-author-id24464208500
person.identifier.scopus-author-id24464652500
person.identifier.scopus-author-id57214054449
person.identifier.scopus-author-id6508057930
rcaap.rightsopenAccessen
rcaap.typeconferenceObjecten
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