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Post-Therapy Epilepsy Prevalence in Patients with High-Grade Gliomas: a systematic review and meta-analysis

2024-11-07Conference object Restricted access
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dc.contributor.authorBorges, Daniel Filipe
dc.contributor.authorSoares, Joana I.
dc.contributor.authorCasalta-Lopes, João
dc.contributor.authorFerreira, Marta Pereira
dc.contributor.authorCarvalho, Ruben
dc.date.accessioned2024-11-14T15:15:54Z
dc.date.available2024-11-14T15:15:54Z
dc.date.issued2024-11-07
dc.description.abstractHigh-grade gliomas are the most common type of malignant glioma. Seizures are frequently the first clinical manifestation of high-grade gliomas. Seizure-control is one of the main goals of treatment due to the impact in quality of life of these patients. Besides it impacts in morbidity and mortality rates there is a lack of evidence in the prevalence of post- therapy epilepsy. Our main goal was to evaluate the prevalence of epilepsy after the end of high-grade gliomas treatment. Our search was conducted across PubMed®️, EMBASE®️, Web of Science™️, Cochrane Library, Sicelo and Scopus, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We included all studies conducted on adults with newly diagnosed high-grade gliomas, who were treated with at least surgery or radiotherapy, and assessed for long-term side-effects (accounting for seizures) and published in Portuguese or English. Thirty-six studies were included in the meta-analysis, encompassing a total of 4036 patients with high-grade gliomas. Patient’s mean age ranged from 44 to 73 years, with a diagnosis of glioblastoma in 77,8% of all patients. Pretreatment seizures were observed in 21,2% of all cases. Surgery was the main treatment for all studies, with 1842 patients undergoing adjuvant therapy. Our meta-analysis identified a pooled prevalence of post-therapy seizures of 25.5%, with a 95% confidence interval of [19.9%;31.1%] (Z=8.90, p<.001). A significant heterogeneity between studies was observed (I2=96%, Q(35)=784, p<.001) with no significant asymmetry in funnel plot analysis (Z=1.27, p=.20). High-grade gliomas are a recognized trigger for seizures. A high heterogeneity in all the evaluated variables was observed. To minimize the diversity of results, a larger prospective studies using appropriate epilepsy diagnostic techniques would be beneficial to have a more exact number of the high-grade glial patients that develop post-therapy epilepsy.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationPereira MP, Carvalho R, Borges DF, Soares JI, Casalta-Lopes J. Post-Therapy Epilepsy Prevalence in Patients with High-Grade Gliomas: A systematic review and meta-analysis. 3º International Congresso of the Portugues Society of Physiology. Portugal, 07 e 08/11/2024. (in print)pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/26400
dc.language.isoengpt_PT
dc.subjectHigh-grade gliomaspt_PT
dc.subjectMalignant gliomapt_PT
dc.subjectEpilepsypt_PT
dc.titlePost-Therapy Epilepsy Prevalence in Patients with High-Grade Gliomas: a systematic review and meta-analysispt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.titleFrontiers Abstract Bookpt_PT
person.familyNameBorges
person.familyNameSoares
person.familyNameCasalta-Lopes
person.familyNameLopes Carvalho
person.givenNameDaniel Filipe
person.givenNameJoana I.
person.givenNameJoão
person.givenNameRuben
person.identifier3235598
person.identifier.ciencia-id0217-87F9-58DF
person.identifier.ciencia-idB81F-1A58-0242
person.identifier.ciencia-idCD1E-B2A2-3E54
person.identifier.orcid0000-0003-0189-7908
person.identifier.orcid0000-0002-3549-6873
person.identifier.orcid0000-0001-5215-7542
person.identifier.ridJVO-1831-2024
person.identifier.scopus-author-id57912703700
person.identifier.scopus-author-id55128240300
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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relation.isAuthorOfPublication60b3d8c2-513c-4fcf-9b0d-0c85bd34ea1b
relation.isAuthorOfPublication6a83294b-dc90-4b21-8f69-a71abfb503fa
relation.isAuthorOfPublication47d5207c-6de6-479e-8580-955a88937f3d
relation.isAuthorOfPublication.latestForDiscovery60b3d8c2-513c-4fcf-9b0d-0c85bd34ea1b

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