Publication
Validation of the Adult Asthma Epidemiological Score: a secondary analysis of EPI-ASTHMA
| dc.contributor.author | Laranjeira, Catarina | |
| dc.contributor.author | Jácome, Cristina | |
| dc.contributor.author | Amaral, Rita | |
| dc.contributor.author | Bernardo, Filipa | |
| dc.contributor.author | Correia-deSousa, Jaime | |
| dc.contributor.author | Fonseca, João A. | |
| dc.contributor.author | Amaral, Rita | |
| dc.date.accessioned | 2025-05-15T14:41:43Z | |
| dc.date.available | 2025-05-15T14:41:43Z | |
| dc.date.issued | 2024-05 | |
| dc.description.abstract | The A2 score is an 8-question patient-reported outcome measure that has been validated for ruling in (score ≥4) and ruling out (score 0-1) asthma. However, this screening tool has been validated in a cohort similar to the derivation cohort used. This study aims to validate the predictive accuracy of the A2 score in a primary care population against general practitioner (GP) clinical assessment and to determine whether the proposed cut-offs are the most appropriate. This accuracy study is a secondary analysis of the EPI-ASTHMA population-based study. Random adult participants recruited from primary healthcare centers in Portugal were analyzed. Participants answered the A2 score by telephone interview. Those with an A2 score ≥1 (plus 5% with an A2 score of 0) were invited to a diagnostic visit carried out by a GP to confirm or not a diagnosis of asthma. Diagnostic accuracy was assessed using receiver operating characteristic (ROC) curves. A total of 1283 participants (median 54[p25-p75 43-66] years; 60% female) were analyzed. The A2 score showed high discriminatory power in identifying asthma, with an area under the ROC curve of 82.9(95%CI 80.4-85.4)%. The proposed cut-off ≥4 was the most appropriate to rule in asthma (specificity 83.1%, positive predictive value 62.4%, accuracy 78%). Similarly, the proposed cut-off <2 was the most suitable for excluding asthma (sensitivity 92.7%, negative predictive value 93.7%, accuracy 60.5%). The A2 score is a useful tool to identify patients with asthma in a primary care population. | por |
| dc.identifier.citation | Laranjeira, C., Jácome, C., Amaral, R., Bernardo, F., Sousa, J. C., & Fonseca. (2024). Validation of the Adult Asthma Epidemiological Score: A secondary analysis of EPI-ASTHMA. Livro de Resumos do 17º Encontro de Investigação Jovem da U.Porto / Book of Abstracts Young Researchers Meeting of U.Porto, 1124. https://www.up.pt/ijup/wp-content/uploads/sites/892/2024/05/Livro-de-Resumos_final.pdf | |
| dc.identifier.isbn | 978-989-746-378-5 | |
| dc.identifier.uri | http://hdl.handle.net/10400.22/30089 | |
| dc.language.iso | eng | |
| dc.peerreviewed | n/a | |
| dc.publisher | Universidade do Porto | |
| dc.relation.hasversion | https://www.up.pt/ijup/wp-content/uploads/sites/892/2024/05/Livro-de-Resumos_final.pdf | |
| dc.rights.uri | N/A | |
| dc.subject | Asthma | |
| dc.subject | Epidemiology | |
| dc.subject | Diagnostic screening | |
| dc.subject | Patient-reported outcome measure | |
| dc.title | Validation of the Adult Asthma Epidemiological Score: a secondary analysis of EPI-ASTHMA | por |
| dc.type | conference poster | |
| dspace.entity.type | Publication | |
| oaire.citation.conferenceDate | 2024-05 | |
| oaire.citation.conferencePlace | Porto | |
| oaire.citation.startPage | 1124 | |
| oaire.citation.title | Livro de Resumos do 17.º Encontro de Investigação Jovem da U.Porto / Book of Abstracts Young Researchers Meeting of U.Porto | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| person.familyName | Amaral | |
| person.givenName | Rita | |
| person.identifier | R-00H-83K | |
| person.identifier.ciencia-id | 1A1E-751F-50F0 | |
| person.identifier.orcid | 0000-0002-0233-830X | |
| person.identifier.rid | E-5535-2017 | |
| person.identifier.scopus-author-id | 56067841600 | |
| relation.isAuthorOfPublication | 790fdd33-acdb-4dfe-88dc-38538486c9b3 | |
| relation.isAuthorOfPublication.latestForDiscovery | 790fdd33-acdb-4dfe-88dc-38538486c9b3 |