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Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni

2019Journal article Open access
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dc.contributor.authorOliveira, Katia C.
dc.contributor.authorCardoso, Rita
dc.contributor.authorDos Santos, Antonio C.
dc.contributor.authorFernandes, Rúben
dc.contributor.authorBotelho, Monica C.
dc.date.accessioned2019-12-05T16:52:26Z
dc.date.available2020-12-10T01:30:25Z
dc.date.issued2019
dc.description.abstractObjective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association in Schistosoma haematobium infection have already been described and it is known that the parasite produces a catechol-estrogen molecule that induces a hormonal imbalance in the host. Methods: In order to better understand the relation of hormonal imbalance in experimental Schistosoma mansoni infection, we investigated a serum panel of steroid hormones in Schistosoma mansoni infected hamsters. Results: We found a decrease in the serum levels of Estradiol (E2), Testosterone and Progesterone in infected females and an increase of Testosterone and a decrease in Progesterone in infected males in comparison with controls. Conclusion: These results indicate that S. mansoni alters the levels of steroid hormones in infected males and females and it will increase the repertoire of data about the host-parasite molecular interplay and its relation with the endocrine system.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOliveira, K. C., Cardoso, R., Santos, A. C. D., Fernandes, R., & Botelho, M. C. (2019). Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni. Endocrine, Metabolic & Immune Disorders - Drug Targets, 19(8), 1122–1126.
dc.identifier.doi10.2174/1871530319666190529121204pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/15046
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationPOCI-01-0145-FEDER- 007274pt_PT
dc.relation.publisherversionhttp://www.eurekaselect.com/172321/articlept_PT
dc.subjectSteroid hormonespt_PT
dc.subjectSchistosoma mansoni infectionpt_PT
dc.subjectHost-parasite interactionpt_PT
dc.subjectEstradiolpt_PT
dc.subjectTestosteronept_PT
dc.subjectProgesteronept_PT
dc.subjectInfertilitypt_PT
dc.titleImbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansonipt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04293%2F2013/PT
oaire.citation.endPage1126pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage1122pt_PT
oaire.citation.titleEndocrine, Metabolic and Immune Disorders - Drug Targetspt_PT
oaire.citation.volume19pt_PT
oaire.fundingStream5876
person.familyNameFernandes
person.givenNameRúben
person.identifier635792
person.identifier.ciencia-id0D1F-4090-E82A
person.identifier.orcid0000-0001-8933-3984
person.identifier.scopus-author-id57640135700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4
relation.isAuthorOfPublication.latestForDiscovery9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4
relation.isProjectOfPublicationa21beac1-88e1-4514-a951-aee8f9dd8cfc
relation.isProjectOfPublication.latestForDiscoverya21beac1-88e1-4514-a951-aee8f9dd8cfc

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