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Comparison of different radiotherapy techniques for locally advanced pancreatic tumors

2019-09Book part Restricted access
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dc.contributor.authorGomes, Adriana
dc.contributor.authorRodrigues, Darlene
dc.contributor.authorCosta Ferreira, Brígida
dc.date.accessioned2021-11-16T10:33:31Z
dc.date.available2021-11-16T10:33:31Z
dc.date.issued2019-09
dc.description.abstractRadiotherapy (RT) associated with systemic therapy is the standard treatment for Locally Advanced Pancreatic Cancer (LAPC). The aim of this study was to compare the efficacy of different RT techniques using the clinical data reported in the literature. Clinical data was collected from scientific papers searched in the databases PubMed and ScienceDirect. Thirty-four documents published between 1997 and 2015 were found and met the inclusion criteria: locally advanced adenocarcinoma, unresectable and no metastasis. Values of Complete Response (CR), Partial Response (PR), Stable Disease (SD), Pro gression Disease, Progression Free Survival (PFS), and Overall Survival (OS) for Three-Dimensional Conformal Radiation Therapy (3DCRT), Intensity Modulated Radiation Therapy (IMRT) and Stereotactic Body Radiotherapy (SBRT) in the treatment of LAPC were collected. For all RT techniques, Response Rate (RR), defined as the sum of CR and PR, was for 3DCRT 25.2% ± 9.5 [range: 5.0%–49.0%], for IMRT 33.5% ± 10.5 [range: 10.6%–55.6%] and for SBRT 52.2% ± 17.7 [range: 13.3%–69.5%]. For all studied techniques, Local Control (LC), defined as the sum of RR and SD, ranged from 47% to 100%; PFS ranged from 4 to 12 months and OS ranged from 6 to 20 months. A significant improvement in overall response rate was obtained with SBRT compared to 3DRCT and IMRT. However, LC, PFS and OS were similar among the three RT techniques.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGomes, A., Rodrigues, D., & Ferreira, B. C. (2019). Comparison of Different Radiotherapy Techniques for Locally Advanced Pancreatic Tumors. In J. Henriques, N. Neves, & P. d. Carvalho (Eds.), XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019 (Vol. 76). Springer. https://doi.org/https://doi.org/10.1007/978-3-030-31635-8_157pt_PT
dc.identifier.doi10.1007/978-3-030-31635-8_157pt_PT
dc.identifier.isbn978-3-030-31634-1
dc.identifier.urihttp://hdl.handle.net/10400.22/18874
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/chapter/10.1007%2F978-3-030-31635-8_157pt_PT
dc.subjectPancreatic cancerpt_PT
dc.subjectRadiotherapy techniquespt_PT
dc.subjectLocal controlpt_PT
dc.subjectSurvivalpt_PT
dc.titleComparison of different radiotherapy techniques for locally advanced pancreatic tumorspt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.conferencePlaceCoimbra - Portugalpt_PT
oaire.citation.endPage1290pt_PT
oaire.citation.startPage1283pt_PT
oaire.citation.titleXV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019pt_PT
oaire.citation.volume76pt_PT
person.familyNameCosta Ferreira
person.givenNameBrigida
person.identifier1167997
person.identifier.ciencia-idA61B-E07B-84B3
person.identifier.orcid0000-0001-7988-7545
person.identifier.scopus-author-id14050253300
rcaap.rightsclosedAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublicationeac8b2c3-0ef3-48f5-a3c7-8ca796a098ae
relation.isAuthorOfPublication.latestForDiscoveryeac8b2c3-0ef3-48f5-a3c7-8ca796a098ae

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