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Deregulated expression of selected histone methylases and demethylases in prostate carcinoma

2013Journal article Open access
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dc.contributor.authorQuintela Vieira, Ana Filipa
dc.contributor.authorCosta-Pinheiro, Pedro
dc.contributor.authorRamalho-Carvalho, João
dc.contributor.authorMenezes, Francisco Duarte
dc.contributor.authorAntunes, Luis
dc.contributor.authorCarneiro, Isa
dc.contributor.authorOliveira, Jorge
dc.contributor.authorHenrique, Rui
dc.contributor.authorJeronimo, Carmen
dc.date.accessioned2014-01-29T16:45:25Z
dc.date.available2014-01-29T16:45:25Z
dc.date.issued2013
dc.description.abstractProstate cancer (PCa), a leading cause of cancer-related morbidity and mortality, arises through the acquisition of genetic and epigenetic alterations. Deregulation of histone methyltransferases (HMTs) or demethylases (HDMs) has been associated with PCa development and progression. However, the precise influence of altered HMTs or HDMs expression and respective histone marks in PCa onset and progression remains largely unknown. To clarify the role of HMTs and HDMs in prostate carcinogenesis, expression levels of 37 HMTs and 20 HDMs were assessed in normal prostate and PCa tissue samples by RT-qPCR. SMYD3, SUV39H2, PRMT6, KDM5A, and KDM6A were upregulated, whereas KMT2A-E (MLL1-5) and KDM4B were downregulated in PCa, compared with normal prostate tissues. Remarkably, PRMT6 was the histone modifier that best discriminated normal from tumorous tissue samples. Interestingly, EZH2 and SMYD3 expression levels significantly correlated with less differentiated and more aggressive tumors. Remarkably, SMYD3 expression levels were of independent prognostic value for the prediction of disease-specific survival of PCa patients with clinically localized disease submitted to radical prostatectomy. We concluded that expression profiling of HMTs and HDMs, especially SMYD3, might be of clinical usefulness for the assessment of PCa patients and assist in pre-therapeutic decision-making.por
dc.identifier.citationVieira FQ, Costa-Pinheiro P, Ramalho-Carvalho J, Pereira A, Menezes FD, Antunes L, Carneiro I, Oliveira J, Henrique R, Jerónimo C. (2013). Deregulated expression of selected histone methylases and demethylases in prostate carcinoma. Endocr Relat Cancer. 16;21(1):51-61. doi: 10.1530/ERC-13-0375. PMID: 24200674.
dc.identifier.doi10.1530/ERC-13-0375
dc.identifier.urihttp://hdl.handle.net/10400.22/3504
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherBioscientificapor
dc.relation.ispartofseriesEndocrine-Related Cancer; Vol. 21, Nº 1
dc.relation.publisherversionhttps://pubmed.ncbi.nlm.nih.gov/24200674/por
dc.subjectProstatepor
dc.subjectNeoplasiapor
dc.subjectMolecular biologypor
dc.subjectBiomarkerpor
dc.subjectMicroarraypor
dc.titleDeregulated expression of selected histone methylases and demethylases in prostate carcinomapor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage61por
oaire.citation.issueNº 1por
oaire.citation.startPage51por
oaire.citation.titleEndocrine-Related Cancerpor
oaire.citation.volumeVol. 21por
person.familyNameQuintela Vieira
person.givenNameAna Filipa
person.identifier.orcid0000-0003-0130-7664
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication47123d10-a0ed-47cc-a751-721489a13446
relation.isAuthorOfPublication.latestForDiscovery47123d10-a0ed-47cc-a751-721489a13446

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