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Electroanalytical study of fluvoxamine
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Orientador(es)
Resumo(s)
Fluvoxamine (FVX) can be reduced at a mercury-
drop electrode, with a maximum peak current
intensity being obtained at a potential of -0.7 V vs. Ag/
AgCl, in an aqueous electrolyte solution of pH 2. The
compound was determined in a pharmaceutical product
and in spiked human serum by square-wave adsorptivestripping
voltammetry (SWAdSV) after accumulation at
the electrode surface, under batch conditions. Because
the presence of dissolved oxygen did not interfere significantly
with the analysis, it was also possible to
determine FVX in the pharmaceutical product by use of
a flow-injection analysis (FIA) system with SWAdSV
detection. The methods developed were validated and
successfully applied to the quantification of FVX in a
pharmaceutical product. Recoveries between 76 and
89% were obtained in serum analysis. The FIA–
SWAdSV method enabled analysis of up to 120 samples
per hour at reduced cost, implying the possibility of
competing with the chromatographic methods usually
used for this analysis.
Descrição
Palavras-chave
Fluvoxamine Square-wave adsorptivestripping voltammetry Flow-injection analysis Electrochemical detection Pharmaceuticals Serum
Contexto Educativo
Citação
Editora
Springer-Verlag