The Role of Mitochondria in Acetyl-L-Carnitine Neuroprotective Action

Cunha, Lídia; Bravo, Joana; Costa, Pedro; Gonçalves, Raquel; Rodrigues, Catarina; Rodrigues, Adriano; Metello, Luís F.; Summavielle, Teresa

http://hdl.handle.net/10400.22/5545

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
COM_MetelloLF_2_2011.pdf		312.15 KB	Adobe PDF	Download

Send Feedback

Authors

Abstract(s)

It is widely known that a number of chronic neurodegenerative disorders are related with dysfunctional mitochondria. Although it has been proposed that Acetyl-L-Carnitine (ALC) confers neuroprotection through mitochondria viability improvement, little is known concerning the molecular mechanisms involved. We propose to characterize the action of ALC in mitochondria bioenergetics and functional integrity.