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Comprehensive Assessment of TERT mRNA Expression across a Large Cohort of Benign and Malignant Thyroid Tumours

2020Journal article Open access
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dc.contributor.authorPestana, Ana
dc.contributor.authorBatista, Rui
dc.contributor.authorCelestino, Ricardo
dc.contributor.authorCanberk, Sule
dc.contributor.authorSobrinho-Simões, Manuel
dc.contributor.authorSoares, Paula
dc.date.accessioned2020-09-14T10:46:35Z
dc.date.available2020-09-14T10:46:35Z
dc.date.issued2020
dc.description.abstractThe presence of TERT promoter (TERTp) mutations in thyroid cancer have been associated with worse prognosis features, whereas the extent and meaning of the expression and activation of TERT in thyroid tumours is still largely unknown. We analysed frozen samples from a series of benign and malignant thyroid tumours, displaying non-aggressive features and low mutational burden in order to evaluate the presence of TERTp mutations and TERT mRNA expression in these settings. In this series, TERTp mutations were found in 2%, only in malignant cases, in larger cancers, and from older patients. TERT mRNA expression was detected in both benign and malignant tumours, with increased frequencies in the malignant tumours with aggressive histotypes, larger tumours, and from older patients. In benign tumours, TERT mRNA expression was found in 17% of the follicular thyroid adenoma (FTA) with increased levels of expression in smaller tumours and associated with the presence of thyroiditis. TERTp mutations and TERT mRNA expression are correlated with worse prognosis features in malignant thyroid tumours, whereas TERT mRNA expression in the benign tumours is associated with the presence of thyroiditis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPestana A, Batista R, Celestino R, Canberk S, Sobrinho-Simões M, Soares P. Comprehensive Assessment of TERT mRNA Expression across a Large Cohort of Benign and Malignant Thyroid Tumours. Cancers. 2020; 12(7):1846. https://doi.org/10.3390/cancers12071846
dc.identifier.doi10.3390/cancers12071846pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/16250
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationPOCI-01-0145-FEDER-007274pt_PT
dc.relationTERT promoter mutations in cancer: from cell immortalization to invasion
dc.relationA comprehensive genetic study to unveil the missing genes predisposing to one of the highest heritable cancers - Familial non-medullar thyroid tumours
dc.relationPOCI-01-0145-FEDER-031438pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2072-6694/12/7/1846pt_PT
dc.subjectThyroid tumourspt_PT
dc.subjectTERT promoter mutationspt_PT
dc.subjectImmortalizationpt_PT
dc.subjectTelomerasept_PT
dc.titleComprehensive Assessment of TERT mRNA Expression across a Large Cohort of Benign and Malignant Thyroid Tumourspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTERT promoter mutations in cancer: from cell immortalization to invasion
oaire.awardTitleA comprehensive genetic study to unveil the missing genes predisposing to one of the highest heritable cancers - Familial non-medullar thyroid tumours
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F110617%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F111321%2F2015/PT
oaire.citation.issue7pt_PT
oaire.citation.startPage1846pt_PT
oaire.citation.titleCancerspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStreamPOR_NORTE
oaire.fundingStreamPOR_NORTE
person.familyNamePestana
person.familyNameCelestino
person.givenNameAna
person.givenNameRicardo
person.identifier154697
person.identifier.ciencia-id0F17-C5B6-D5B5
person.identifier.ciencia-id301A-7536-FFE2
person.identifier.orcid0000-0003-0200-4059
person.identifier.orcid0000-0002-9605-6433
person.identifier.ridJ-6048-2013
person.identifier.scopus-author-id56404350600
person.identifier.scopus-author-id57195924601
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isProjectOfPublication43350ef2-d526-40ba-b913-5603233b96c8
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