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Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease

2022-05-23Journal article Restricted access
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dc.contributor.authorFernandes, Filipe
dc.contributor.authorBarroso, M. Fátima
dc.contributor.authorDe Simone, Angela
dc.contributor.authorEmriková, Eliška
dc.contributor.authorDias-Teixeira, Mónica
dc.contributor.authorPereira, José Paulo
dc.contributor.authorChlebek, Jakub
dc.contributor.authorFernandes, Virgínia Cruz
dc.contributor.authorRodrigues, Francisca
dc.contributor.authorAndrisano, Vincenza
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorGrosso, Clara
dc.date.accessioned2023-01-27T15:31:18Z
dc.date.embargo2035
dc.date.issued2022-05-23
dc.description.abstractEthnopharmacological relevance Alzheimer's disease is the most common form of dementia, but its treatment options remain few and ineffective. To find new therapeutic strategies, natural products have gained interest due to their neuroprotective potential, being able to target different pathological hallmarks associated with this disorder. Several plant species are traditionally used due to their empirical neuroprotective effects and it is worth to explore their mechanism of action. Aim of the study This study intended to explore the neuroprotective potential of seven traditional medicinal plants, namely Scutellaria baicalensis, Ginkgo biloba, Hypericum perforatum, Curcuma longa, Lavandula angustifolia, Trigonella foenum-graecum and Rosmarinus officinalis. The safety assessment with reference to pesticides residues was also aimed. Materials and methods Decoctions prepared from these species were chemically characterized by HPLC-DAD and screened for their ability to scavenge four different free radicals (DPPH•, ABTS•+, O2•‒ and •NO) and to inhibit enzymes related to neurodegeneration (cholinesterases and glycogen synthase kinase-3β). Cell viability through MTT assay was also evaluated in two different brain cell lines, namely non-tumorigenic D3 human brain endothelial cells (hCMEC/D3) and NSC-34 motor neurons. Furthermore, and using GC, 21 pesticides residues were screened. Results Regarding chemical composition, chromatographic analysis revealed the presence of several flavonoids, phenolic acids, curcuminoids, phenolic diterpenoids, one alkaloid and one naphthodianthrone in the seven decoctions. All extracts were able to scavenge free radicals and were moderate glycogen synthase kinase-3β inhibitors; however, they displayed weak to moderate acetylcholinesterase and butyrylcholinesterase inhibition. G. biloba and L. angustifolia decoctions were the less cytotoxic to hCMEC/D3 and NSC-34 cell lines. No pesticides residues were detected. Conclusions The results extend the knowledge on the potential use of plant extracts to combat multifactorial disorders, giving new insights into therapeutic avenues for Alzheimer's disease.pt_PT
dc.description.sponsorshipThis research was funded by UIDB/50006/2020, UIDP/50006/2020, and MTS/SAS/0077/2020 from the Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through national funds. Clara Grosso, Francisca Rodrigues and Fátima Barroso are thankful for their contracts (CEECIND/03436/2020, CEECIND/01886/2020; CEECIND/03107/2020) financed by FCT/MCTES—CEEC Individual 2020 Program Contract. Virginia Cruz Fernandes and F. Fernandes thank FCT for the financial support through a postdoctoral fellowship (SFRH/BPD/109153/2015) and a PhD fellowship (2021.06806.BD), respectivelypt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.jep.2022.115107pt_PT
dc.identifier.issn0378-8741
dc.identifier.urihttp://hdl.handle.net/10400.22/21960
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relationCEECIND/01886/2020pt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationFruitec-Modern analytical technologies for assess Persistent and Emergent Organic Pollutants in red fruits
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0378874122001453?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAlzheimer’s diseasept_PT
dc.subjectPlant extractspt_PT
dc.subjectCholinesterasespt_PT
dc.subjectGlycogen synthase kinase-3βpt_PT
dc.subjectOxidative stresspt_PT
dc.subjectPesticides residuespt_PT
dc.titleMulti-target neuroprotective effects of herbal medicines for Alzheimer's diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleFruitec-Modern analytical technologies for assess Persistent and Emergent Organic Pollutants in red fruits
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/MTS%2FSAS%2F0077%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBPD%2F109153%2F2015/PT
oaire.citation.startPage115107pt_PT
oaire.citation.titleJournal of Ethnopharmacologypt_PT
oaire.citation.volume290pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStreamPOR_NORTE
person.familyNameFernandes
person.familyNamede Sá Barroso
person.familyNameFernandes
person.familyNamePinto Lisboa Martins Rodrigues Sarmento
person.familyNameDelerue-Matos
person.familyNameGrosso
person.givenNameFilipe
person.givenNameMaria de Fátima
person.givenNameVirgínia
person.givenNameFrancisca
person.givenNameCristina
person.givenNameAna Clara
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person.identifier.ciencia-id711B-1170-4C32
person.identifier.orcid0000-0002-2931-8536
person.identifier.orcid0000-0001-9011-5992
person.identifier.orcid0000-0003-3979-7523
person.identifier.orcid0000-0001-8803-0041
person.identifier.orcid0000-0002-3924-776X
person.identifier.orcid0000-0002-2457-8267
person.identifier.ridG-4985-2010
person.identifier.ridD-4990-2013
person.identifier.ridB-9813-2013
person.identifier.scopus-author-id57222077374
person.identifier.scopus-author-id25631648000
person.identifier.scopus-author-id37045954500
person.identifier.scopus-author-id6603741848
person.identifier.scopus-author-id25627935200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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