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Gestational Weight Gain and Offspring Bone Mass: Different Associations in Healthy Weight Versus Overweight Women

2019Journal article Open access
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dc.contributor.authorMonjardino, Teresa
dc.contributor.authorHenriques, Ana
dc.contributor.authorMoreira, Carla
dc.contributor.authorRodrigues, Teresa
dc.contributor.authorAdubeiro, Nuno
dc.contributor.authorNogueira, Luísa
dc.contributor.authorCooper, Cyrus
dc.contributor.authorSantos, Ana Cristina
dc.contributor.authorLucas, Raquel
dc.date.accessioned2019-06-27T16:36:46Z
dc.date.available2020-05-02T00:30:30Z
dc.date.issued2019
dc.description.abstractWeight management strategies during pregnancy reduce child cardiometabolic risk. However, because maternal weight has an overall positive correlation with offspring bone mass, pregnancy weight management could adversely affect child bone health. We aimed to estimate associations between gestational weight gain (GWG) and bone mineralization in the offspring at 7 years of age, and test early pregnancy body mass index (BMI) as an effect modifier. We analyzed prospective data from 2167 mother-child pairs from the Generation XXI birth cohort who underwent whole-body dual-energy X-ray absorptiometry at 7 years of age. GWG was analyzed as a continuous measure and using the Institute of Medicine categories. In the whole sample and for each early pregnancy BMI category (under/normal weight and overweight/obese), relationships between GWG and offspring bone measures (bone mineral content [BMC], bone areal density [aBMD], size-corrected BMC [scBMC], and height) at 7 years were fitted through local polynomial regression and smoothing splines. The magnitude of associations was estimated through linear regression coefficients (95% CIs), crude and adjusted for maternal age, height, educational level, and child gestational age. In under/normal weight mothers, GWG was associated with slightly increased bone measures at 7 years (per 5 kg of GWG, BMC: 0.07 SD [95% CI, 0.01 to 0.12]; aBMD: 0.10 SD [95% CI, 0.05 to 0.15], scBMC: 0.11SD [95% CI, 0.06 to 0.16], and height: 0.05 SD [95% CI, 0.00 to 0.10]), while in overweight/obese mothers no effect of GWG on bone was observed (BMC: 0.02 SD [95% CI, -0.04 to 0.09]; aBMD: 0.02 SD [95% CI, -0.04 to 0.08], scBMC: 0.01 SD [95% CI, -0.06 to 0.08], and height: 0.02 SD [95% CI, -0.04 to 0.08]). Also, no advantageous effect of gaining weight above the Institute of Medicine recommendations was observed in either early pregnancy BMI group. Our results suggest that adherence to Institute of Medicine recommendations for pregnancy weight gain is unlikely to have a negative repercussion on offspring bone health, particularly in women with excess weight in early pregnancy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/jbmr.3587pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14137
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationPTDC/DTP‐EPI/1687/2014pt_PT
dc.relationPTDC/DTP‐EPI/3306/2014pt_PT
dc.relationPOCI‐01‐0145‐FEDER‐016838pt_PT
dc.relationPOCI‐01‐0145‐FEDER‐016837pt_PT
dc.relationPOCI‐01‐0145‐FEDER‐006862pt_PT
dc.relationIDENTIFYING SENSITIVE PERIODS FOR THE EFFECTS OF ADIPOSITY AND GLUCOSE METABOLISM ON PEDIATRIC BONE: A BIRTH COHORT APPROACH
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1002/jbmr.3587pt_PT
dc.subjectCOHORT STUDYpt_PT
dc.subjectBONE DENSITYpt_PT
dc.subjectGESTATIONAL WEIGHT GAINpt_PT
dc.subjectBODY MASS INDEXpt_PT
dc.titleGestational Weight Gain and Offspring Bone Mass: Different Associations in Healthy Weight Versus Overweight Womenpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIDENTIFYING SENSITIVE PERIODS FOR THE EFFECTS OF ADIPOSITY AND GLUCOSE METABOLISM ON PEDIATRIC BONE: A BIRTH COHORT APPROACH
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FDTP%2F04750%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F92370%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F88729%2F2012/PT
oaire.citation.endPage48pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage38pt_PT
oaire.citation.titleJournal of Bone and Mineral Researchpt_PT
oaire.citation.volume34pt_PT
oaire.fundingStream5876
oaire.fundingStreamFARH
oaire.fundingStreamSFRH
person.familyNameAdubeiro
person.givenNameNuno
person.identifier.ciencia-id0119-2885-C797
person.identifier.orcid0000-0001-8657-3288
person.identifier.ridAAC-1663-2021
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication35d1aa21-3c2a-4af6-8346-efa61cd513fc
relation.isAuthorOfPublication.latestForDiscovery35d1aa21-3c2a-4af6-8346-efa61cd513fc
relation.isProjectOfPublication679167f9-f039-4e55-b9b3-212706ab558b
relation.isProjectOfPublication77aae1db-f76e-4252-a0c5-cf29644ce7d5
relation.isProjectOfPublicationfad19f23-7a3b-41e1-bc86-00e8dfe1c80b
relation.isProjectOfPublication.latestForDiscovery679167f9-f039-4e55-b9b3-212706ab558b

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