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Advisor(s)
Abstract(s)
Celiac disease (CD) is an autoimmune enteropathy,
characterized by an inappropriate T-cell-mediated
immune response to the ingestion of certain dietary cereal
proteins in genetically susceptible individuals. This disorder
presents environmental, genetic, and immunological components.
CD presents a prevalence of up to 1% in
populations of European ancestry, yet a high percentage
of cases remain underdiagnosed. The diagnosis and
treatment should be made early since untreated disease
causes growth retardation and atypical symptoms, like
infertility or neurological disorders. The diagnostic criteria
for CD, which requires endoscopy with small bowel biopsy,
have been changing over the last few decades, especially
due to the advent of serological tests with higher sensitivity and specificity. The use of serological markers can be very
useful to rule out clinical suspicious cases and also to help
monitor the patients, after adherence to a gluten-free diet.
Since the current treatment consists of a life-long glutenfree
diet, which leads to significant clinical and histological
improvement, the standardization of an assay to assess in an
unequivocal way gluten in gluten-free foodstuff is of major
importance.
Description
Keywords
Celiac disease Autoimmune Transglutaminase Gliadin
Citation
Publisher
Springer-Verlag