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Improving the antimycobacterial drug Clofazimine through formation of organic salts by combination with fluoroquinolones

2023-01-11Journal article Open access
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dc.contributor.authorBento, Clara M.
dc.contributor.authorSilva, Ana Teresa
dc.contributor.authorMansano, Bruno
dc.contributor.authorAguiar, Luísa
dc.contributor.authorTeixeira, Cátia
dc.contributor.authorGomes, Maria Salomé
dc.contributor.authorGomes, Paula
dc.contributor.authorSilva, Tânia
dc.contributor.authorFerraz, Ricardo
dc.date.accessioned2023-03-17T17:05:46Z
dc.date.available2023-03-17T17:05:46Z
dc.date.issued2023-01-11
dc.description.abstractThis work reports the synthesis, structural and thermal analysis, and in vitro evaluation of the antimicrobial activity of two new organic salts (OSs) derived from the antimycobacterial drug clofazimine and the fluoroquinolones ofloxacin or norfloxacin. Organic salts derived from active pharmaceutical ingredients (API-OSs), as those herein disclosed, hold promise as cost-effective formulations with improved features over their parent drugs, thus enabling the mitigation of some of their shortcomings. For instance, in the specific case of clofazimine, its poor solubility severely limits its bioavailability. As compared to clofazimine, the clofazimine-derived OSs now reported have improved solubility and thermostability, without any major deleterious effects on the drug’s bioactivity profile.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBento, C. M., Silva, A. T., Mansano, B., Aguiar, L., Teixeira, C., Gomes, M. S., Gomes, P., Silva, T., & Ferraz, R. (2023). Improving the Antimycobacterial Drug Clofazimine through Formation of Organic Salts by Combination with Fluoroquinolones. International Journal of Molecular Sciences, 24(2), 1402. https://doi.org/10.3390/ijms24021402pt_PT
dc.identifier.doi10.3390/ijms24021402pt_PT
dc.identifier.eissn1422-0067
dc.identifier.urihttp://hdl.handle.net/10400.22/22536
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/24/2/1402pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntibioticspt_PT
dc.subjectGUMBOSpt_PT
dc.subjectIonic liquidspt_PT
dc.subjectMycobacteriumpt_PT
dc.subjectOrganic saltspt_PT
dc.subjectRepurposingpt_PT
dc.subjectRescuingpt_PT
dc.titleImproving the antimycobacterial drug Clofazimine through formation of organic salts by combination with fluoroquinolonespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage11pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume24(2)pt_PT
person.familyNameFerraz
person.givenNameRicardo
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.orcid0000-0002-1761-117X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication.latestForDiscoverya5a8faa7-12a5-4b1c-bced-44c895677397

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