Repository logo
 
Publication

Characterization of disease progression in the initial stages of retinopathy in type 2 diabetes: A 2-year longitudinal study

2020-08Journal article Open access
Simple item page
dc.contributor.authorMarques, Inês P.
dc.contributor.authorAlves, Dalila
dc.contributor.authorSantos, Torcato
dc.contributor.authorMendes, Luís
dc.contributor.authorLobo, Conceição
dc.contributor.authorSantos, Ana Rita
dc.contributor.authorDurbin, Mary
dc.contributor.authorCunha-Vaz, José
dc.date.accessioned2021-10-22T09:05:28Z
dc.date.available2021-10-22T09:05:28Z
dc.date.issued2020-08
dc.description.abstractTo characterize 2-year changes occurring in neurodegeneration, edema, and capillary dropout in nonproliferative diabetic retinopathy. Two-year prospective longitudinal observational cohort of eyes/patients with type 2 diabetes using spectral domain optical coherence tomography (SD-OCT) and opti cal coherence tomography angiography (OCTA). Eyes were examined three times with intervals of 1 year. Thickness of the full retina and layer-by-layer measurements were used to identify edema or neurodegeneration. OCTA vessel density maps of the retina were used to identify capillary dropout. Early Treatment Diabetic Retinopathy Study (ETDRS) classification was performed using the seven-field ETDRS protocol. A total of 62 eyes from 62 patients with diabetes were followed for 2 years. After verification for image quality, a total of 44 eyes from 44 patients (30% women) aged 52 to 80 years were retained for data analysis. There were 18 eyes with ETDRS grades 10 to 20, 17 eyes with ETDRS grade 35, and 9 eyes with ETDRS grades 43 to 47. During the 2-year follow-up period, there was a progressive increase in capillary dropout, whereas edema and neurodegeneration remained stable. In multivariate analysis, consid ering a model adjusted for age, sex, hemoglobin A1C, visual acuity, and diabetes duration, vessel density remained significantly different between Diabetic Retinopathy Severity Scale groups (Wilks’ λ = 0.707; P = 0.015) showing association with disease progression. Capillary dropout increased in a period of 2 years in eyes with minimal, mild, and moderate diabetic retinopathy, whereas the presence of edema and neurodegeneration remained stablept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMarques, I. P., Alves, D., Santos, T., Mendes, L., Lobo, C., Santos, A. R., Durbin, M., & Cunha-Vaz, J. (2020). Characterization of Disease Progression in the Initial Stages of Retinopathy in Type 2 Diabetes: A 2-Year Longitudinal Study. Investigative Ophthalmology and Visual Science, 61(3), 20-20. https://doi.org/10.1167/iovs.61.3.20pt_PT
dc.identifier.doi10.1167/iovs.61.3.20pt_PT
dc.identifier.issn1552-5783
dc.identifier.urihttp://hdl.handle.net/10400.22/18765
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherARVOpt_PT
dc.relation.publisherversionhttps://iovs.arvojournals.org/article.aspx?articleid=2763258&resultClick=1pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectRetinopathypt_PT
dc.subjectDiabetespt_PT
dc.titleCharacterization of disease progression in the initial stages of retinopathy in type 2 diabetes: A 2-year longitudinal studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage8pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleInvestigative Ophthalmology & Visual Sciencept_PT
oaire.citation.volume61pt_PT
person.familyNameSantos
person.givenNameAna Rita
person.identifier.ciencia-id0911-4138-0C3A
person.identifier.orcid0000-0003-0139-0285
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd71931b8-d869-4334-993c-ba14ad713f01
relation.isAuthorOfPublication.latestForDiscoveryd71931b8-d869-4334-993c-ba14ad713f01

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ART_Ana Rita Santos (2).pdf
Size:
2.35 MB
Format:
Adobe Portable Document Format
Download

Collections

ESS - ORT - Artigos