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Betulinic acid and obesity-related disorders

2025-09-23Research article Open access
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dc.contributor.authorAzevedo, Lara
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorVieira, Mónica
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorFernandes, Sílvia
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorAlmeida Vieira, Mónica Andreia
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorFernandes, Sílvia
dc.date.accessioned2025-12-16T09:51:52Z
dc.date.available2025-12-16T09:51:52Z
dc.date.issued2025-09-23
dc.description.abstractThe obesity epidemic is not just a health issue, it is increasingly driving a shift in the prevalence of chronic diseases, affecting 890 million adults and straining healthcare systems worldwide. Conditions such as type 2 diabetes mellitus, cardiovascular diseases, non-alcoholic fatty liver disease, and various cancer types are closely tied to this growing crisis. Betulinic acid has anti-inflammatory, antioxidant and anti-cancer properties and modulates key metabolic pathways such as NF-κB and AMPK signaling. This compound improves insulin sensitivity, reduces hepatic steatosis, mitigates the progression of atherosclerosis and fibrosis, and suppresses inflammatory responses, which are important in treating those obesity-related disorders. Additionally, betulinic acid use in cancer treatment has been explored due to its potential in angiogenesis and metastasis inhibition and promotion of apoptosis. This review spotlights the therapeutic potential of the natural compound betulinic acid in processes such as insulin sensitivity, glucose and lipid metabolism, adiposity, inflammation, oxidative stress, intestinal microbiota, and other mechanisms underlying different obesity-related disorders. Overall, besides strong therapeutic potential of betulinic acid, described limitations such as poor aqueous solubility, limited bioavailability, production and extraction have resulted in scarce clinical data making it premature to draw definitive conclusions regarding its application in clinical practice.por
dc.identifier.citationAzevedo, L., Ferraz, R., Vieira, M., Prudêncio, C., & Fernandes, S. (2025). Betulinic acid and obesity-related disorders. Frontiers in Pharmacology, 16. https://doi.org/10.3389/fphar.2025.1674713
dc.identifier.doi10.3389/fphar.2025.1674713
dc.identifier.eissn1663-9812
dc.identifier.urihttp://hdl.handle.net/10400.22/31208
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers
dc.relationUID/50006
dc.relation.hasversionhttps://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1674713/full
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHealth
dc.subjectObesity
dc.subjectBetulinic acid
dc.subjectCancer
dc.subjectApoptosis
dc.subjectDisorders
dc.titleBetulinic acid and obesity-related disorderseng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Pharmacology
oaire.citation.volume16
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFerraz
person.familyNameAlmeida Vieira
person.familyNamePrudêncio
person.familyNameFernandes
person.givenNameRicardo
person.givenNameMónica Andreia
person.givenNameCristina
person.givenNameSílvia
person.identifier1200571
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.ciencia-idA01E-9178-9B48
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.ciencia-idFB1A-1376-32B8
person.identifier.orcid0000-0002-1761-117X
person.identifier.orcid0000-0002-8687-4811
person.identifier.orcid0000-0002-9920-936X
person.identifier.orcid0000-0003-2031-0658
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
person.identifier.scopus-author-id6508057930
person.identifier.scopus-author-id57195931190
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
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relation.isAuthorOfPublication.latestForDiscoverya5a8faa7-12a5-4b1c-bced-44c895677397

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