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Preconcentration and sensitive determination of the anti-inflammatory drug diclofenac on a paper-based electroanalytical platform

2019-10-03Journal article Open access
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dc.contributor.authorCosta-Rama, E.
dc.contributor.authorNouws, H.
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorBlanco-López, M.C.
dc.contributor.authorFernández-Abedul, M.T.
dc.date.accessioned2020-07-10T13:06:10Z
dc.date.available2020-07-10T13:06:10Z
dc.date.issued2019-10-03
dc.description.abstractThis work describes the development of a paper-based platform for highly sensitive detection of diclofenac. The quantification of this anti-inflammatory drug is of importance in clinical (e.g. quality and therapeutic control) and environmental (e.g. emerging contaminant determination) areas. The easy-to-handle platform here described consists of a carbon-ink paper-based working electrode and two metallic wires, provided by a gold-plated standard connector, as reference and counter electrodes. The porous paper matrix enables the preconcentration of the sample, decoupling sample and detection solutions. Thus, relatively large sample volumes can be used, which significantly improves the sensitivity of the method. A wide dynamic range of four orders of magnitude, between 0.10 and 100 μM, was obtained for diclofenac determination. Due to the predominance of adsorption at the lowest concentrations, there were two linear concentration ranges: one comprised between 0.10 and 5.0 μM (with a slope of 0.85 μA μM-1) and the other between 5.0 and 100 μM (with a slope of 0.48 μA μM-1). A limit of detection of 70 nM was achieved with this simple device that provided accurate results with an RSD of ca. 5%. The platform was applied for diclofenac quantification in spiked tap water samples. The versatility of this design enabled the fabrication of a multiplexed platform containing eight electrochemical cells that work independently. The low cost, small size and simplicity of the device allow on-site analysis, which is very useful for environmental monitoring.pt_PT
dc.description.sponsorshipThe authors would like to thank the EU and FCT/UEFISCDI/FORMAS for funding, in the frame of the collaborative internationalconsortium REWATERfinanced under the ERA-NET CofundWaterWorks 2015 Call. This ERA-NET is an integral part of the 2016Joint Activities developed by the Water Challenges for a ChangingWorld Joint Programme Initiative (Water JPI). This work was alsosupported by the EU (FEDER funds through COMPETE) and FCT(project FOODnanoHEALTH, Portugal2020, Norte-01-0145-FEDER-000011 and project UID/QUI/50006/2013) and by the SpanishMinistry of Economy and Competitiveness (MINECO, projectCTQ2014-58826-R). Estefanía Costa Rama thanks the Governmentof Principado de Asturias and Marie Curie-Cofund Actions for thepost-doctoral grant“Clarín-Cofund”ACA17-20.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.aca.2019.05.016pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/16091
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0003267019305720?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPaper-based electroanalysispt_PT
dc.subjectElectroanalytical platformspt_PT
dc.subjectMultiplexingpt_PT
dc.subjectLow-cost analysispt_PT
dc.subjectAnti-inflammatory drugspt_PT
dc.subjectDiclofenacpt_PT
dc.titlePreconcentration and sensitive determination of the anti-inflammatory drug diclofenac on a paper-based electroanalytical platformpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.citation.endPage97pt_PT
oaire.citation.startPage89pt_PT
oaire.citation.titleAnalytica Chimica Actapt_PT
oaire.citation.volume1074pt_PT
oaire.fundingStream5876
person.familyNameNouws
person.familyNameDelerue-Matos
person.givenNameHendrikus
person.givenNameCristina
person.identifier1046746
person.identifier.ciencia-id9B1A-9CED-6EE3
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0002-1472-8866
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridD-5249-2013
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id7801450247
person.identifier.scopus-author-id6603741848
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication.latestForDiscovery2c48191f-fb0f-44a5-9435-88912f2a4bbc
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