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Appraisal of a new potential antioxidants-rich nutraceutical ingredient from chestnut shells through in-vivo assays – A targeted metabolomic approach in phenolic compounds

2023Journal article Open access
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dc.contributor.authorPinto, Diana
dc.contributor.authorAlmeida, Andreia
dc.contributor.authorLópez-Yerena, Anallely
dc.contributor.authorPinto, Soraia
dc.contributor.authorSarmento, Bruno
dc.contributor.authorLamuela-Raventós, Rosa
dc.contributor.authorVallverdú-Queralt, Anna
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorRodrigues, Francisca
dc.date.accessioned2023-03-15T10:21:00Z
dc.date.available2023-03-15T10:21:00Z
dc.date.issued2023
dc.description.abstractChestnut (Castanea sativa) shells (CSS) are a source of bioactive compounds with well demonstrated in-vitro antioxidant properties. Nevertheless, no in-vivo studies have already evaluated this effect. This study evaluated the effects of the oral daily administration of an eco-friendly CSS extract (50 and 100 mg/kg per body weight (b. w.)) to rats regarding in-vivo antioxidant activity, glucose and lipids levels, and metabolomic profiling of poly- phenols by LC-ESI-LTQ-Orbitrap-MS. The results demonstrated the in-vivo antioxidant properties in the animals liver, kidney and blood serum, as well as protective effects against hemolysis and rising of blood glucose and lipids levels. New insights on metabolomic profiling of polyphenols proved their absorption and further biotransformation by phase I (hydrogenation and hydroxylation) and II reactions (glucuronidation, methylation and sulfation). This is the first study that attempted to validate a novel nutraceutical ingredient extracted from CSS by in-vivo assays, corroborating the outcomes screened by in-vitro assayspt_PT
dc.description.sponsorshipThe authors’ kindly thanks to Sortegel (Sortes, Portugal) for the samples. This work received financial support from national funds (UIDB/50006/2020), project PTDC/ASP-AGR/29277/2017 - Castanea sativa shells as a new source of active ingredients for Functional Food and Cosmetic applications: a sustainable approach, and project 5537 DRI, Sérvia 2020/21 from Portuguese-Serbia Bilateral Cooperation - Development of functional foods incorporating a chestnut shells extract obtained by subcritical water, supported by national funds by FCT / MCTES and co-supported by Fundo Europeu de Desenvolvimento Regional (FEDER) throughout COMPETE 2020 - Programa Operacional Competitividade e Internacionalização (POCI-01-0145-FEDER-029277). Diana Pinto (SFRH/BD/144534/2019) and Soraia Pinto (SFRH/BD/144719/2019) are thankful for their PhD grants financed by FCT/MCTES and POPH-QREN and supported by funds from European Union (EU) and Fundo Social Europeu (FSE) through Programa Operacional Regional Norte. Francisca Rodrigues is grateful for her contract (CEECIND/01886/2020) financed by FCT/MCTES—CEEC Individual 2020 Program Contract. Anna Vallverdú-Queralt thanks the Spanish Ministerio de Ciencia, Innovación y Universidades for the Ramon y Cajal contract (RYC-2016-19355).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.foodchem.2022.134546pt_PT
dc.identifier.issn0308-8146
dc.identifier.urihttp://hdl.handle.net/10400.22/22493
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relationCEECIND/01886/2020pt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationCastanea sativa shells as a new source of active ingredients for Functional Food and Cosmetic applications: a sustainable approach
dc.relationCastanea sativa shells: An industrial by-product as source of active ingredients for functional foods
dc.relationOral delivery of semaglutide through multifunctional FcRn-peptide targeting nanoparticles for treatment of type 2 diabetes mellitus
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0308814622025080pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCastanea sativapt_PT
dc.subjectSubcritical water extractionpt_PT
dc.subjectPolyphenolspt_PT
dc.subjectIn-vivo studypt_PT
dc.subjectNutraceuticalpt_PT
dc.subjectMetabolomicpt_PT
dc.titleAppraisal of a new potential antioxidants-rich nutraceutical ingredient from chestnut shells through in-vivo assays – A targeted metabolomic approach in phenolic compoundspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleCastanea sativa shells as a new source of active ingredients for Functional Food and Cosmetic applications: a sustainable approach
oaire.awardTitleCastanea sativa shells: An industrial by-product as source of active ingredients for functional foods
oaire.awardTitleOral delivery of semaglutide through multifunctional FcRn-peptide targeting nanoparticles for treatment of type 2 diabetes mellitus
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FASP-AGR%2F29277%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F144534%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F144719%2F2019/PT
oaire.citation.startPage134546pt_PT
oaire.citation.titleFood Chemistrypt_PT
oaire.citation.volume404pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamPOR_NORTE
person.familyNamePinto
person.familyNameAlmeida
person.familyNameDelerue-Matos
person.familyNamePinto Lisboa Martins Rodrigues Sarmento
person.givenNameDiana
person.givenNameAndreia
person.givenNameCristina
person.givenNameFrancisca
person.identifier1660692
person.identifier.ciencia-id591C-826B-9BF4
person.identifier.ciencia-idA21D-BF4F-0BF9
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.ciencia-id4F19-3D98-2CBA
person.identifier.orcid0000-0001-8534-3739
person.identifier.orcid0000-0001-6186-8696
person.identifier.orcid0000-0002-3924-776X
person.identifier.orcid0000-0001-8803-0041
person.identifier.ridE-4350-2017
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id56527841500
person.identifier.scopus-author-id56701827500
person.identifier.scopus-author-id6603741848
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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